Гемфиброзил
Гемфиброзил атрибут
| Температура плавления: |
61-63°C |
| Температура кипения: |
158-159 C |
| плотность: |
1.1109 (rough estimate) |
| показатель преломления: |
1.5020 (estimate) |
| температура хранения: |
2-8°C |
| растворимость: |
Практически нерастворим в воде, хорошо растворим в хлористом метилене, легко растворим в безводном этаноле и метаноле. |
| форма: |
пудра |
| пка: |
4.75±0.45(Predicted) |
| цвет: |
От белого до не совсем белого |
| Растворимость в воде: |
> 0,5 г/л (температура не указана) |
| Мерк: |
14,4388 |
| BCS Class: |
2 |
| Справочник по базе данных CAS: |
25812-30-0(CAS DataBase Reference) |
| FDA UNII: |
Q8X02027X3 |
| Предложение 65 Список: |
Gemfibrozil |
| Словарь наркотиков NCI: |
gemfibrozil |
| Код УВД: |
C10AB04 |
| МАИР: |
3 (Vol. 66) 1996 |
| Система регистрации веществ EPA: |
Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl- (25812-30-0) |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
| символ（GHS） |
|
| сигнальное слово |
Warning |
| Заявление об опасности |
| пароль |
Заявление об опасности |
Класс опасности |
категория |
сигнальное слово |
пиктограмма |
предупреждение |
| H302 |
Вредно при проглатывании. |
Острая токсичность, пероральная |
Категория 4 |
Предупреждение |
|
P264, P270, P301+P312, P330, P501 |
|
| Внимание |
| P301+P312+P330 |
ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью
при плохом самочувствии. Прополоскать рот. |
|
Гемфиброзил химические свойства, назначение, производство
Описание
Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 μM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.
Химические свойства
White Crystalline Powder
Использование
Gemfibrozil has been used to to study its effects on cell cycle progression in yeast. It has been used to study the effects of fibrates on cell proliferation and gene expression in human cell lines.
Всемирная организация здравоохранения(ВОЗ)
Gemfibrozil, an antihyperlipidaemic derivative of clofibrate, was
introduced in the early 1980's. It is registered in several countries for the treatment
of hyperlipidaemia unresponsive to dietary measures. (See also the WHO comment
for clofibrate).
Общее описание
Gemfibrozil, 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (Lopid), is a congener of clofibratethat was used first in the treatment of hyperlipoproteinemia inthe mid-1970s. Its mechanism of action and use are similar tothose of clofibrate. Gemfibrozil reduces plasma levels ofVLDL triglycerides and stimulates clearance of VLDL fromplasma. The drug has little effect on cholesterol plasma levelsbut does cause an increase of HDL.
Gemfibrozil is absorbed quickly from the gut and excretedunchanged in the urine. The drug has a plasma half-life of1.5 hours, but reduction of plasma VLDL concentration takesbetween 2 and 5 days to become evident. The peak effect of its hypolipidemic action may take up to 4 weeks to becomemanifest.
Механизм действия
From the chemical point of view, gemfibrozil is somewhat related to clofibrate and has
analogous pharmacological use. The primary action of gemibrozil as well as clofibrate
consists of a significant reduction in the level of very low-density proteins in the plasma
and an increase in high-density protein formation.
Гемфиброзил препаратная продукция и сырье
сырьё
препарат
Гемфиброзил поставщик
Global( 429)Suppliers
25812-30-0(Гемфиброзил)подобный поиск: