2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- атрибут
| Температура плавления: |
276 °C |
| плотность: |
1.577±0.06 g/cm3(Predicted) |
| температура хранения: |
Sealed in dry,Store in freezer, under -20°C |
| растворимость: |
нерастворим в EtOH; нерастворим в H2O; ≥16,85 мг/мл в ДМСО |
| пка: |
9.84±0.43(Predicted) |
| форма: |
Твердое вещество от белого до желтого цвета. |
| цвет: |
White to Orange to Green |
| FDA UNII: |
B4W27J1Z8B |
Заявления о рисках и безопасности
2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- химические свойства, назначение, производство
Описание
Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers. CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM). It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50s = 31-125 nM). CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.
Использование
CL-387785 (EKI-785) is an irreversible and selective EGFR inhibitor showing activity against mutations of the receptor. Potential therapeutic against various type of cancer, including lung cancer.
Определение
ChEBI: A member of the class of quinazolines that is 4,6-diaminoquinazoine in which the one of the hydrogens attached to the amino group at position 4 has been replaced by a m-bromophenyl group while one of the hydrogens attached to the amino group a
position 6 has been replaced by a but-2-ynoyl group.
2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- препаратная продукция и сырье
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2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- поставщик
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