4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
![4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide](/CAS/GIF/188591-46-0.GIF)
- CAS:
- 188591-46-0
- MF:
- C15H12ClF3N2O3S
- MW:
- 392.78
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Company Type
Properties
- Boiling point:
- 585.1±50.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- pka
- 12.92±0.46(Predicted)
- form
- White solid
- color
- white to off-white
- Stability:
- Stable for 1 year for up to year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H319
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P
- Hazard Codes
- Xi
- Risk Statements
- 36
- Safety Statements
- 26
- WGK Germany
- 3
Use
PPARβ/δ is thought to play a role in lipid homeostasis and glucose disposal by regulating genes involved in fatty acid oxidation, reverse cholesterol transport, and carbon substrate utilization in skeletal muscle. It has also been implicated in the progression of certain cancers. GSK3787 is an irreversible antagonist of PPARβ/δ (pIC50 = 6.6) with no measurable affinity for PPARα or PPARγ (pIC50 5). At 1μM, it inhibits the expression of PPARβ/δ-regulated target genes, pyruvate dehydrogenase kinase 4 and carnitine palmitoyl transferase 1a, which are important for energy homeostasis in human skeletal muscle cells. GSK3787 (at 1 μM) also antagonizes agonist-induced expression of angiopoietin-like protein 4 in mouse fibroblasts, mouse keratinocytes, and human MCF-7, Huh7, and HepG2 cancer cell lines.[Cayman Chemical]
1 India supplier list of "4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide"
- Product Name:GSK3787
- Products Intro:Brand:sigma aldrich | Product Number:G7423 | Purity:≥98%(HPLC),whitetooff-white,powder
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Gsk3787 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.171173
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:GSK3787
- Products Intro:Brand:ajchemicals | Product Number:JDH-30727 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
- Products Intro:Purity: 99% | Package: 1.8KG;9.8USD
- Company Type: Trader
- Country/Region: CHINA
$9.80/ 1.8KG
- Product Name:GSK3787
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:GSK-3787
- Products Intro:Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for GSK-3787.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
- Products Intro:Purity: 0.95&0.99 | Package: 0.1KG;1KG;1000KG | CustNote: Top Quality
- Company Type: Trader
- Country/Region: CHINA
- Product Name:GSK3787
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: GSK3787
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
- Product Name:4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
- Products Intro:CustNote: https://www.alfa-chemistry.com/4-chloro-n-2-5-trifluoromethyl-2-pyridinyl-sulfonyl-ethyl-benzamide-cas-188591-46-0-item-290776.htm
- Company Type: Reagent
- Country/Region: UNITED STATES
- Main Products: Active Pharmaceutical Ingredient (API),Insect Pheromone,Boronic Compounds,Material & Chemicals,Lipid Compounds