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(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE

(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE

CAS:
745055-91-8
MF:
C15H15N3O6
MW:
333.3

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Company Type

Properties

Melting point:
207.9-208.5 °C (decomp)(Solv: water (7732-18-5))
Boiling point:
603.0±65.0 °C(Predicted)
Density 
1.525±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: ≥5mg/mL at 60°C (with warming for 5 minutes)
pka
2.12±0.10(Predicted)
form 
powder
color 
white to off-white

Safety Information

Symbol(GHS) 

GHS07
Signal word 
Warning
Hazard statements 
H302
Precautionary statements 
P264-P270-P301+P312-P330-P501
Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3

Use

Selective and potent GLU K5 (GluR5)-subunit containing kainate receptor antagonist (apparent K D = 402 nM); active enantiomer of UBP 296 ((RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione ). Displays ~ 260-fold selectivity over AMPA receptors. UBP 296 displays ~ 90-fold selectivity over recombinant human GLU K6 - and GLU K2 -containing kainate receptors, has little or no action at NMDA or group I mGlu receptors and selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibres.

0 India supplier list of "(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE"

  • Product Name:UBP 302
  • Products Intro:Package: 10 mg;2 mg;5 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
  • Product Name:UBP 302
  • Products Intro:Purity: NLT 98% | CustNote: MC569934
  • Company Type: Manufacturer
  • Country/Region: CHINA
  • Main Products: 2432-11-3,1052686-50-6,2198-53-0,3769-42-4,83647-42-1
  • Product Name:UBP 302
  • Products Intro:Purity: >=98%(HPLC) | Package: $1088.9/10mg;$4900.9/50mg;Bulk package | CustNote: 98%(HPLC)
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
  • 5mg$173.00
    25mg$664.00
  • Product Name:UBP302
  • Products Intro:Brand: Sigma-Aldrich | Product Number: U4135 | Purity: ≥98% (HPLC)
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Main Products: cof,mof
  • 1 mg$45.00
    5 mg$158.00
  • Product Name:UBP 302
  • Products Intro:Brand: Caymanchem | Product Number: 24309 | Purity: ≥98%
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Main Products: cof,mof
  • 10 mg$269.00
    50 mg$1115.00
  • Product Name:(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
  • Products Intro:Brand: Tocris Bioscience | Product Number: 2079 | Purity: ≥98% (HPLC)
  • Company Type: Trader
  • Country/Region: UNITED KINGDOM
  • Main Products: cof,mof
  • Product Name:UBP302
  • Products Intro:Brand:dcchemicals | Product Number:DC22748 | Purity:>98%
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • 5mg$650.00
    10mg$1100.00
  • Product Name:UBP302
  • Products Intro:Brand:ChemScene | Product Number:CS-0028945 | Purity:>99.0%
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Product Name:UBP302
  • Products Intro:Brand:glenthamls | Product Number:GL9765
  • Company Type: Trader
  • Country/Region: UNITED KINGDOM
  • 1mg$123.00
    5mg$302.00
  • Products Intro:Brand:1pchem | Product Number:1P00FF1R | Purity:≥98%
  • Company Type: Trader
  • Country/Region: UNITED STATES
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