Cladribine
Cladribine
- CAS:
- 4291-63-8
- MF:
- C10H12ClN5O3
- MW:
- 285.69
Suppliers by country/region
Company Type
Properties
- Melting point:
- 181-185 °C(lit.)
- alpha
- D25 -18.8° (c = 1 in DMF)
- Boiling point:
- 547.6±60.0 °C(Predicted)
- Density
- 2.03±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Slightly soluble in water, soluble in dimethyl sulfoxide, slightly soluble in methanol, practically insoluble in acetonitrile. It shows polymorphism (5.9).
- pka
- 13.75±0.60(Predicted)
- form
- White solid
- color
- White to Pale Yellow
- λmax
- 265nm(EtOH aq.)(lit.)
- Merck
- 14,2337
- Stability:
- Store in Freezer
- InChIKey
- PTOAARAWEBMLNO-HSUXUTPPSA-N
Safety Information
- Symbol(GHS)
GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H301-H341-H361fd-H372
- Precautionary statements
- P201-P202-P260-P264-P270-P301+P310
- Hazard Codes
- T
- Risk Statements
- 36/37/38-23/24/25
- Safety Statements
- 26-37/39-45-36-22
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- RTECS
- AU7357560
- HS Code
- 29349990
- Toxicity
- LD50 intraperitoneal in mouse: 150mg/kg
Use
Cladribine, an adenosine deaminase inhibitor, was introduced in the United States as a single intravenous treatment for hairy cell leukemia. The incorporation of a chlorine atom at the 2-position of deoxyadenosine renders cladribine more resistant to enzymatic attack by adenosine deaminase, resulting in a more prolonged cytotoxic effect. Cladribine efficiently crosses lymphocyte and monocyte cell membranes and is metabolized in cells to the biologically active triphosphate, which inhibits DNA synthesis. While most antineoplastic drugs are active primarily against dividing cells, cladribine destroys both resting and proliferating cells. Its potential uses in the treatment of autoimmune hemolytic anemia, multiple sclerosis, chronic lymphocytic leukemia and various lymphomas have also been evaluated.
23 India supplier list of "Cladribine"
- Product Name:Cladribine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Cladribine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Cladribine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Cladribine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Cladribine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:2-Chloro-2′-deoxyadenosine
- Products Intro:Brand:sigma aldrich | Product Number:C4438 | Purity:antileukemic
- Company Type: Trader
- Country/Region: Bangalore,INDIA