Rifampicin manufacturers and suppliers in india

Rifampicin

Properties

Melting point:: 183°C (dec.)

Boiling point:: 761.02°C (rough estimate)

Density: 1.1782 (rough estimate)

refractive index: 1.6000 (estimate)

storage temp.: 2-8°C

solubility: chloroform: soluble50mg/mL, clear

pka: 1.7, 7.9(at 25℃)

form: crystalline

color: faint red to very dark red

Water Solubility: Soluble in DMSO or methanolSoluble in water, ethyl acetate, chloroform, methanol, tetrahydrofuran and dimethyl sulfoxide.

Merck: 14,8216

BRN: 5723476

BCS Class: 2

Stability:: Hygroscopic, Light Sensitive

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335-H362

Precautionary statements: P260-P263-P301+P312-P302+P352-P305+P351+P338-P308+P313

Hazard Codes: Xn,Xi

Risk Statements: 22-36/37/38-36/38

Safety Statements: 26-36-37/39

WGK Germany: 3

RTECS: VJ7000000

F: 8-10-21

HS Code: 29419000

Toxicity: LD50 in mice, rats (mg/kg): 885, 1720 orally; 260, 330 i.v.; 640, 550 i.p. (Fürész)

Use

Rifampicin and other compounds of the ansamycin group specifically inhibit DNA-dependent RNA polymerase; that is, they prevent the transcription of RNA species from the DNA template. Rifampicin is an extremely efficient inhibitor of the bacterial enzyme, but fortunately eukaryotic RNA polymerase is not affected. RNA polymerase consists of a core enzyme made up of four polypeptide subunits, and rifampicin specifically binds to the subunit where it blocks initiation of RNA synthesis, but is without effect on RNA polymerase elongation complexes. The structural mechanism for inhibition of bacterial RNA polymerase by rifampicin has recently been elucidated. The antibiotic binds to the subunit in a pocket which directly blocks the path of the elongating RNA chain when it is two to three nucleotides in length. During initiation the transcription complex is particularly unstable and the binding of rifampicin promotes dissociation of short unstable RNA DNA hybrids from the enzyme complex. The binding pocket for rifampicin, which is absent in mammalian RNA polymerases, is some 12 away from the active site.