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Trimethoprim

Trimethoprim

CAS:
738-70-5
MF:
C14H18N4O3
MW:
290.32

Properties

Melting point:
199-203 °C
Boiling point:
432.41°C (rough estimate)
Density 
1.1648 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
white powder
pka
6.6(at 25℃)
color 
colorless or white
Water Solubility 
<0.1 g/100 mL at 24 ºC
Merck 
14,9709
BRN 
625127
BCS Class
2
Stability:
Stable. Incompatible with strong oxidizing agents, acids.

Safety Information

Symbol(GHS) 

GHS07
Signal word 
Warning
Hazard statements 
H302
Precautionary statements 
P264-P270-P301+P312-P501
Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45-24/25
RIDADR 
3249
WGK Germany 
3
RTECS 
UV8225000
8-10-21
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29335995
Toxicity
LD50 orally in mice: 7000 mg/kg (Yamamoto)

Use

Trimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine or 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine) is closely related to several antimalarialsbut does not have good antimalarial activity by itself; it is,however, a potent antibacterial. Originally introduced incombination with sulfamethoxazole, it is now available as asingle agent.Approved by the FDA in 1980, trimethoprim as a singleagent is used only for the treatment of uncomplicatedurinary tract infections. The argument for trimethoprim asa single agent was summarized in 1979 by Wormser andDeutsch. They point out that several studies comparingtrimethoprim with TMP–SMX for the treatment ofchronic urinary tract infections found no statistically relevantdifference between the two courses of therapy.The concern is that when used as a single agent, bacterianow susceptible to trimethoprim will rapidly developresistance. In combination with a sulfonamide, however,the bacteria will be less likely to do so. That is, they willnot survive long enough to easily develop resistance toboth drugs.

13 India supplier list of "Trimethoprim"

  • Product Name:Trimethoprim
  • Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
  • Company Type: Trader
  • Country/Region: Maharashtra,INDIA
  • Product Name:Trimethoprim
  • Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
  • Company Type: Manufacturer
  • Country/Region: Telangana,INDIA
  • Product Name:Trimethoprim
  • Products Intro:Brand:sigma aldrich | Product Number:16967 | Purity:certifiedreferencematerial,TraceCERT?
  • Company Type: Trader
  • Country/Region: Bangalore,INDIA
  • Product Name:Trimethoprim 99% (HPLC)
  • Products Intro:Brand:Glrinnovations | OriginalID:GLR19.070817
  • Company Type: Trader
  • Country/Region: New Delhi,INDIA
  • Product Name:Trimethoprim
  • Company Type: Trader
  • Country/Region: New Delhi,INDIA
  • Product Name:Trimethoprim
  • Company Type: Trader
  • Country/Region: New Delhi,INDIA
  • Product Name:Trimethoprim
  • Company Type: Reagent
  • Country/Region: Maharashtra,INDIA
  • Product Name:Trimethoprim
  • Company Type: Reagent
  • Country/Region: Mumbai,INDIA
  • Product Name:Trimethoprim
  • Company Type: Trader
  • Country/Region: New Delhi,INDIA
  • Product Name:TRIMETHOPRIM
  • Company Type: Manufacturer
  • Country/Region: New Delhi,INDIA

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