Trimethoprim
Trimethoprim
- CAS:
- 738-70-5
- MF:
- C14H18N4O3
- MW:
- 290.32
Suppliers by country/region
Company Type
Properties
- Melting point:
- 199-203 °C
- Boiling point:
- 432.41°C (rough estimate)
- Density
- 1.1648 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble
- form
- white powder
- pka
- 6.6(at 25℃)
- color
- colorless or white
- Water Solubility
- <0.1 g/100 mL at 24 ºC
- Merck
- 14,9709
- BRN
- 625127
- BCS Class
- 2
- Stability:
- Stable. Incompatible with strong oxidizing agents, acids.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P501
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 45-24/25
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- UV8225000
- F
- 8-10-21
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29335995
- Toxicity
- LD50 orally in mice: 7000 mg/kg (Yamamoto)
Use
Trimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine or 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine) is closely related to several antimalarialsbut does not have good antimalarial activity by itself; it is,however, a potent antibacterial. Originally introduced incombination with sulfamethoxazole, it is now available as asingle agent.Approved by the FDA in 1980, trimethoprim as a singleagent is used only for the treatment of uncomplicatedurinary tract infections. The argument for trimethoprim asa single agent was summarized in 1979 by Wormser andDeutsch. They point out that several studies comparingtrimethoprim with TMP–SMX for the treatment ofchronic urinary tract infections found no statistically relevantdifference between the two courses of therapy.The concern is that when used as a single agent, bacterianow susceptible to trimethoprim will rapidly developresistance. In combination with a sulfonamide, however,the bacteria will be less likely to do so. That is, they willnot survive long enough to easily develop resistance toboth drugs.
13 India supplier list of "Trimethoprim"
- Product Name:Trimethoprim
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: Maharashtra,INDIA
- Product Name:Trimethoprim
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Trimethoprim
- Products Intro:Brand:sigma aldrich | Product Number:16967 | Purity:certifiedreferencematerial,TraceCERT?
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Trimethoprim
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Trimethoprim
- Company Type: Reagent
- Country/Region: Mumbai,INDIA