AFLATOXIN B1
AFLATOXIN B1
- CAS:
- 1162-65-8
- MF:
- C17H12O6
- MW:
- 312.27
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Company Type
Properties
- Melting point:
- 268-269 °C
- alpha
- D -558° (c = 0.1 in CHCl3); D -480° (c = 0.1 in DMF)
- Boiling point:
- 372.21°C (rough estimate)
- Density
- 1.2810 (rough estimate)
- refractive index
- 1.4800 (estimate)
- Flash point:
- 2 °C
- storage temp.
- 2-8°C
- solubility
- DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 12 mg/ml
- form
- White to yellow powder.
- color
- White to yellow
- Water Solubility
- 15mg/L(temperature not stated)
- Merck
- 13,180
- BRN
- 1269174
- Stability:
- Stable. Incompatible with strong oxidizing agents. May be light or air sensitive.
- InChIKey
- OQIQSTLJSLGHID-WNWIJWBNSA-N
- LogP
- 2.039 (est)
Safety Information
- Symbol(GHS)
GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H300+H310+H330-H340-H350-H361
- Precautionary statements
- P201-P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
- Hazard Codes
- T+,T,Xn,F
- Safety Statements
- 53-45-36-26-16-24-7-62-36/37-28
- RIDADR
- UN 3462 6.1/PG 1
- WGK Germany
- 3
- RTECS
- GY1925000
- F
- 10
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 29322090
- Toxicity
- LD50 orally in day old duckling: 18.2 mg/50 gm body wt (Carnaghan); i.p. in newborn mice: 9.50 mg/kg body wt (Büchi)
Use
Aflatoxin B1 can be activated via the monooxygenase reaction which then reacts with the N7 atom of B-DNA guanine. Conjugation of aflatoxin B1 8,9-epoxide is an important detoxification route. Although aflatoxin B1 8,9-epoxide can be hydrolyzed to the diol by epoxide hydrolase, the diol product is toxic, since it reacts readily with proteins by Schiff base formation or binds to DNA. Glutathione conjugation prevents toxicity of both the epoxide and its hydrolysis product. The aflatoxin glutathione conjugate is subsequently excreted from the hepatocyte into bile as a major biliary metabolite.
1 India supplier list of "AFLATOXIN B1"
- Product Name:AflatoxinB1
- Products Intro:Brand:sigma aldrich | Product Number:32754 | Purity:referencematerial
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Aflatoxin
- Products Intro:Brand:pharmaffiliates | Product Number:PA0129000
- Company Type: Trader
- Country/Region: INDIA
- Product Name:AflatoxinB1
- Products Intro:Brand:synzeal | Product Number:120443022
- Company Type: Trader
- Country/Region: INDIA
- Product Name:AFLATOXIN B1
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:AFLATOXIN B1
- Products Intro:Purity: 99.0% | Package: 1KG;|25KG
- Company Type: Trader
- Country/Region: CHINA
$0.00-0.00 / 1KG
- Product Name:AFLATOXIN B1
- Products Intro:Purity: 99% | Package: 25KG
- Company Type: Service provider
- Country/Region: CHINA
$0.00/ 25KG
- Product Name: AFLATOXIN B1
- Products Intro:Purity: 99% | Package: 1KG;8USD|25KG;6USD|100KG;1USD
- Company Type: Trader
- Country/Region: CHINA
$8.00-1.00 / 1KG