Amantadine
Amantadine
- CAS:
- 768-94-5
- MF:
- C10H17N
- MW:
- 151.25
Suppliers by country/region
Company Type
Properties
- Melting point:
- 206-208 °C(lit.)
- Boiling point:
- 263.29°C (rough estimate)
- Density
- 0.9510 (rough estimate)
- refractive index
- 1.5220 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- 1 M HCl: soluble5%, clear to hazy, colorless to faint yellow or tan
- form
- Powder
- pka
- 10.1(at 25℃)
- color
- White to cream
- Water Solubility
- Soluble in organic solvents. Insoluble in water.
- Merck
- 14,374
- BRN
- 2204333
- InChIKey
- DKNWSYNQZKUICI-UHFFFAOYSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P301+P312+P330-P302+P352-P305+P351+P338
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- YD1925000
- F
- 10-34
- HS Code
- 29213000
- Toxicity
- LD50 oral in rat: 900mg/kg
Use
Amantadine has been used for years as a treatment for Parkinson disease. The adamantanamines have twomechanisms in common:they inhibit an early step in viralreplication, most likely viral uncoating,and in somestrains, they affect a later step that probably involves viral assembly,possibly by interfering with hemagglutinin processing.The main biochemical locus of action is the influenzatype A virus M2 protein, which is an integral membrane proteinthat functions as an ion channel. The M2 channel is a protontransport system. By interfering with the function of theM2 protein, the adamantanamines inhibit acid-mediated dissociationof the ribonucleoprotein complex early in replication.They also interfere with transmembrane proton pumping,maintaining a high intracellular proton concentrationrelative to the extracellular concentration and enhancingacidic pH-induced conformational changes in the hemagglutininduring its intracellular transport at a later stage. The conformationalchanges in hemagglutinin prevent transfer of thenascent virus particles to the cell membrane for exocytosis.
7 India supplier list of "Amantadine"
- Product Name:1-Adamantylamine
- Products Intro:Brand:sigma aldrich | Product Number:138576 | Purity:97%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Adamantan-1-amine 97%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.024941
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Amantadine
- Products Intro:Brand:synzeal | Product Number:192903341
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Amantadine
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:1-Adamantylamine
- Products Intro:Brand:clearsynth | Product Number:CS-O-00927
- Company Type: Trader
- Country/Region: INDIA
- Product Name:adamantan-1-amine
- Products Intro:Brand:thermofisher.in | Product Number:160470050 | Purity:96%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Amantadine
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Amantadine
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Amantadine
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Amantadine
- Company Type: Reagent
- Country/Region: INDIA