AMBRETTOLIDE manufacturers and suppliers in india

AMBRETTOLIDE

Properties

Boiling point:: 185-190 °C16 mm Hg(lit.)

Density: 0.956 g/mL at 25 °C(lit.)

vapor pressure: 0.003Pa at 25℃

refractive index: n20/D 1.479(lit.)

FEMA: 4145 | ISOAMBRETTOLIDE

Flash point:: >230 °F

storage temp.: Refrigerator

solubility: Chloroform (Sparingly), Methanol (Sparingly)

form: Oil

color: Clear Colorless

Odor: at 10.00 % in dipropylene glycol. sweet musk ambrette fruity waxy fatty

Odor Type: musk

Water Solubility: 15μg/L at 25℃

JECFA Number: 1991

LogP: 6.7 at 23℃

Safety Information

Symbol(GHS): GHS09

Signal word: Warning

Hazard statements: H410

Precautionary statements: P273-P391-P501

Hazard Codes: Xi

Risk Statements: 36

Safety Statements: 26-36

WGK Germany: 2

Toxicity: Both the acute oral LD₅₀ value in rats and the acute dermal LD₅₀ value in rabbits exceeded 5 g/kg(Wohl, 1974).

Use

AMBRETTOLIDE is not reported as being found in nature, in contrast to (Z)-7-hexadecen-16-olide, which occurs in ambrette seed oil and which is also referred to as ambrettolide. It is a colorless to slightly yellow liquid, d204 0.949–0.957, n20D 1.477–1.482, with an intense and powerful musk odor. It is prepared by treating aleuritic acid (9,10,16-trihydroxyhexadecanoic acid) with trimethyl orthoformate to give a dioxolane derivative. Reaction with acetic anhydride yields ??-acetoxy (E)-9-hexadecenoic acid methyl ester. This is lactonized with potassium hydroxide to give the title compound .