Aminoglutethimide manufacturers and suppliers in india

Aminoglutethimide

Properties

Melting point:: 152-154 °C(lit.)

Boiling point:: 374.44°C (rough estimate)

Density: 1.1099 (rough estimate)

refractive index: 1.6450 (estimate)

storage temp.: 2-8°C

solubility: H₂O: 0.2 mg/mL, slightly soluble

pka: 11.60±0.40(Predicted)

form: Solid

color: white

Water Solubility: Soluble in water (2 mg/ml at 20°C), methanol (50 mg/ml), ethanol (7 mg/ml at 25°C), DMSO (20 mg/ml at 25°C), and chloroform.

Merck: 14,440

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

RIDADR: 3249

WGK Germany: 3

RTECS: MA4026950

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 2925190100

Use

Aminoglutethimide, a weak anticonvulsant, was introduced in 1960 for use in the treatment of epilepsy. However, its adrenocortical suppressant activity gave rise to serious adverse effects. The FDA decision in 1966 was taken in respect of a preparation indicated in epilepsy. In 1980 preparations containing aminoglutethimide were reintroduced in the USA exclusively for the treatment of Cushing's disease. In 1986 they were also registered in Saudi Arabia for use in Cushing's syndrome and for the treatment of breast cancer. In some other countries these preparations are additionally approved for carcinoma of the prostate.