AMPRENAVIR
AMPRENAVIR
- CAS:
- 161814-49-9
- MF:
- C25H35N3O6S
- MW:
- 505.63
Suppliers by country/region
Company Type
Properties
- Melting point:
- 72-74°C
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 11.54±0.46(Predicted)
- color
- white to beige
- optical activity
- [α]/D +8 to +12°, c = 0.5 in methanol
- BCS Class
- 2
- InChIKey
- YMARZQAQMVYCKC-OEMFJLHTSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H332-H335
- Precautionary statements
- P261-P280-P305+P351+P338
- RIDADR
- 3077
- WGK Germany
- 3
- HS Code
- 29350090
Use
Amprenavir was launched as Agenerase in the US for the treatment of AIDS patients in combination with approved agent antiretroviral nucleoside analogs. It is the fifth non-peptidic inhibitor of HIV-1 protease to be marketed in this indication after the last approved Neflinavir. Amprenavir, designed via a structure-based process, is the smallest molecule in the 《navir》 class and exhibits a reduced peptidic character. An improved process for preparation comprising four steps from a (1S, 2R)-2-hydroxy-3-aminopropylcarbamate has been developed. Amprenavir is a potent inhibitor of HIV-1 aspartyl protease (Ki = 0.6nM), an enzyme required by the virus to cleave pro-form polyproteins to structural proteins during the last stage in the replication process. The compound displays good oral bioavailability in humans and penetrates the CNS, which is an important advantage in long-term treatment. Its plasma half-life is approximately 10h. Treatment with Amprenavir in combination with nucleoside analog reverse transcriptase inhibitors considerably decreases viral load and restores CD4+ T-cell counts in patients with HIV infection.
3 India supplier list of "AMPRENAVIR"
- Product Name:Amprenavir
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Amprenavir
- Products Intro:Brand:sigma aldrich | Product Number:SML0685 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:AMPRENAVIR
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Amprenavir
- Products Intro:Brand:pharmaffiliates | Product Number:PA2893000
- Company Type: Trader
- Country/Region: Haryana,INDIA