Andrographolide manufacturers and suppliers in india

Andrographolide

Properties

Melting point:: 229-232 °C (lit.)

Boiling point:: 557.3±50.0 °C(Predicted)

alpha: -126 º (c=1.5,HAc)

Density: d421 1.2317

storage temp.: 2-8°C

solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml).

pka: 12.36±0.20(Predicted)

form: Off-white solid

color: Off-white

optical activity: [α]20/D 126°, c = 1.5 in acetic acid

λmax: 223nm(MeOH)(lit.)

Merck: 14,633

BRN: 42762

Stability:: Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

InChIKey: BOJKULTULYSRAS-QPSYGYIJSA-N

LogP: 0.424 (est)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H332-H335

Precautionary statements: P261-P280-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 20/21/22-36/37/38

Safety Statements: 22-24/25-36-26

WGK Germany: 3

RTECS: LU3490750

HS Code: 29322980

Use

Andrographolide is a labdane diterpenoid. Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata. It has a broad range of therapeutic applications including anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic properties. Andrographolide showed significant antihepatotoxic action in P. berghei K173- induced hepatic damage in M. natalensis. Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases. These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.