ANTIMYCIN A1
ANTIMYCIN A1
- CAS:
- 642-15-9
- MF:
- C28H40N2O9
- MW:
- 548.63
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Properties
- Melting point:
- 149.5℃
- alpha
- D26 +76° (c = 1 in chloroform)
- Boiling point:
- 620.81°C (rough estimate)
- Density
- 1.2468 (rough estimate)
- refractive index
- 1.5800 (estimate)
- storage temp.
- −20°C
- solubility
- DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
- form
- A solid
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301-H311-H331
- Precautionary statements
- P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 36/37/39-45
- RIDADR
- 3172
- RTECS
- NY1503500
- HazardClass
- 6.1(a)
- PackingGroup
- II
Use
Antimycin A1 is the most hydrophobic of the four analogues of the antimycin A complex. Like all antimycins, antimycin A1 exhibits potent antifungal, anthelmintic, insecticidal, antiviral and antitumor activity across a range of bioassays. Although broadly active as respiration inhibitors, more recent investigation has highlighted the importance of individual members of the complex as bioprobes. Antimycin A1 inhibits angiogenesis via a decrease in VEGF production caused by inhibition of HIF-1a activation.
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