azidamfenicol
azidamfenicol
- CAS:
- 13838-08-9
- MF:
- C11H13N5O5
- MW:
- 295.254
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Properties
- Melting point:
- 107°
- alpha
- D20 -20° (c = 1.6 in ethyl acetate)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Ethyl Acetate (Slightly, Sonicated), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
Use
Azidamfenicol is a semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide, first synthesised at Bayer in 1959. Azidamfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Azidamfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Azidamfenicol has received little research attention with only a few literature citations.
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