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Ethyl nitrite was formerly available in over-the-counter preparations for use as a diaphoretic, a diuretic and an intestinal antispasmodic. In the 1970s its use was associated with cases of methaemoglobinaemia, some of which were fatal. This led to its withdrawal in 1980 by the United States Food and Drug Administration. WHO has no information regarding its current availability in pharmaceutical preparations.
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