EW-7197
EW-7197
- CAS:
- 1352608-82-2
- MF:
- C22H18FN7
- MW:
- 399.42
Suppliers by country/region
Company Type
Properties
- Melting point:
- >85oC (dec.)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 8.51±0.10(Predicted)
- form
- Solid
- color
- Pale Yellow to Light Yellow
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Use
EW-7197 is a novel ALK-5 kinase inhibitor as well as TGF- Type I Receptor Kinase Inhibitor. Study has shown that it can potently inhibit the breast to lung metastasis. Mice study has demonstrated that EW-7197 inhibited Smad/TGF signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice. EW-7197 also inhibited the epithelial-to-mesenchymal transition (EMT) in both TGF-treated breast cancer cells and 4T1 orthotopic-grafted mice. Furthermore, EW-7197 enhanced cytotoxic T lymphocyte activity in 4T1 orthotopic-grafted mice and increased the survival time of 4T1-Luc and 4T1 breast tumor-bearing mice. It can also inhibit hepatic, renal, and pulmonary fibrosis by blocking TGF-/Smad and ROS signaling. Therefore, it is a potential antitumor reagent.
1 India supplier list of "EW-7197"
- Product Name:EW-7197 98% (HPLC)
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.030713
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:EW7197
- Products Intro:Brand:ajchemicals | Product Number:JDH-30090 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:EW7197
- Products Intro:Brand:clearsynth | Product Number:CS-T-75950
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:EW-7197
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:EW-7197
- Products Intro:Purity: >98% | Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for EW-7197.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:EW-7197
- Products Intro:Purity: 98 | Package: 1ASSAYS;1USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Methyl 3-amino-2-fluorobenzoate
- Product Name:EW-7197
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Vactosertib
- Products Intro:Purity: 98% | Package: 1g,5g,25g,500g,1kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 528-94-9,AMMONIUM SALICYLATE,Linolenic acid,463-40-1,931-36-2
- Product Name:Vactosertib (EW-7197)
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceuticals,intermediates,fine chemicals,screening compounds,building blocks
- Product Name:Vactosertib (TEW-7197)
- Products Intro:Purity: 98% | Package: $18.9/1mg;$78.9/5mg;$117.9/10mg;$197.9/25mg;$305.9/50mg;$474.9/100mg;$1068.9/250 | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies