FILGRASTIM
FILGRASTIM
- CAS:
- 121181-53-1
- MF:
- W99
- MW:
- 0
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Company Type
Properties
- storage temp.
- -70°C
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Warning
- Hazard statements
- H361
- Precautionary statements
- P201-P202-P281-P308+P313-P405-P501
- HS Code
- 3002905150
- Toxicity
- LD50 oral in rat: > 3mg/kg
Use
Filgrastim, G-CSF, Neupogen, stimulates the proliferation ofgranulocytes (especially neutrophils) by mobilizinghematopoietic stem cells in the bone marrow. The native protein is glycosylated.Filgrastim selectively stimulates proliferation and differentiationof neutrophil precursors in the bone marrow. Thisleads to the release of mature neutrophils into the circulationfrom the bone marrow. Filgrastim also affects mature neutrophilsby enhancing phagocytic activity, priming the cellularmetabolic pathways associated with the respiratoryburst, enhancing antibody-dependent killing, and increasingthe expression of some functions associated with cell surfaceantigens.In patients receiving chemotherapy with drugs such ascyclophosphamide, doxorubicin, and etoposide, the incidenceof neutropenia accompanied by fever is rather high.Administration of G-CSF reduces the time of neutrophilrecovery and duration of fever in adults with acute myelogenousleukemia. The number of infections, days thatantibiotics are required, and duration of hospitalization arealso reduced.
1 India supplier list of "FILGRASTIM"
- Product Name:Filgrastim
- Products Intro:Brand:pharmaffiliates | Product Number:PA061610000
- Company Type: Trader
- Country/Region: INDIA
- Product Name:FILGRASTIM
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:FILGRASTIM
- Products Intro:Purity: 99.9%|Package: 1g;1.1USD
- Company Type: Trader
- Country/Region: CHINA
$1.10/ 1g