Isoquinoline manufacturers and suppliers in india

Isoquinoline

Properties

Melting point:: 26-28 °C (lit.)

Boiling point:: 242-243 °C (lit.)

Density: 1.099 g/mL at 25 °C (lit.)

vapor pressure: 5Pa at 20℃

FEMA: 2978 | ISOQUINOLINE

refractive index: n20/D 1.623(lit.)

Flash point:: 225 °F

storage temp.: 2-8°C

solubility: 5g/l

form: Low Melting Solid

pka: 5.42(at 20℃)

color: Light brown

PH: 7.5 (5g/l, H2O, 20℃)

Odor: at 0.10 % in triacetin. sweet balsam herbal benzaldehyde anise

Odor Type: balsamic

Water Solubility: practically insoluble

Merck: 14,5222

JECFA Number: 1303

BRN: 107549

Dielectric constant: 10.7（20℃）

InChIKey: AWJUIBRHMBBTKR-UHFFFAOYSA-N

LogP: 2.08

Dissociation constant: 5.19 at 25℃

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H302-H311-H315-H319-H412

Precautionary statements: P264-P273-P280-P301+P312-P302+P352+P312-P305+P351+P338

Hazard Codes: T

Risk Statements: 22-24-38-52/53-36/38-21/22-45

Safety Statements: 36/37-45-36/37/39-61-53

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 2

RTECS: NW6825000

TSCA: Yes

HazardClass: 6.1

PackingGroup: II

HS Code: 29334900

Toxicity: LD50 orally in rats: 360 mg/kg (Smyth)

Use

Crude quinoline containing 83% quinoline, 15% isoquinoline and 2% methyl quinoline can be used as the raw material for the production of isoquinoline. However, the Distillation section from 237.5-239.5℃ and 243-246℃ is generally collected and used as the raw material for the extraction of isoquinoline. 13-28% of 2-methyl quinoline and 3.9% quinoline can be separated from this distillation section in the form of hydrochloride salt. The isoquinoline fraction reacted with 98% sulfuric acid at 35℃ in alcohol solution to produce isoquinoline sulfonate. Isoquinoline sulfonate crystallizes faster than its homologues in the cooling process. After filtration, recrystallization was carried out with 85% ethanol, and then decomposed with 20% ammonia water. The generated oil layer was firstly washed with water, and then rectified to collect the fraction at242-243℃to obtain Isoquinoline with purity greater than 95% It is separated by repeated freezing the coal tar with the boiling rangeat 238～250℃.