Lamotrigine
Lamotrigine
- CAS:
- 84057-84-1
- MF:
- C9H7Cl2N5
- MW:
- 256.09
Suppliers by country/region
- India(173)
- China(182)
- United States(64)
- Singapore(1)
- United Kingdom(25)
- Canada(10)
- Germany(9)
- Switzerland(3)
- The Netherlands(2)
- Europe(2)
- Israel(3)
- Nigeria(1)
- Spain(5)
- Brazil(3)
- Mexico(2)
- Nepal(1)
- France(4)
- Malaysia(1)
- United Arab Emirates(1)
- Iran(1)
- South Korea(4)
- Poland(6)
- Slovenia(1)
- Czech Republic(1)
- Colombia(1)
- Japan(1)
- Italy(1)
- Oman(1)
- Hungary(1)
- Greece(1)
Company Type
Properties
- Melting point:
- 177-181°C
- Boiling point:
- 503.1±60.0 °C(Predicted)
- Density
- 1.572±0.06 g/cm3(Predicted)
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- DMSO: 20 mg/mL at 60 °C, soluble
- form
- powder
- pka
- 5.7(at 25℃)
- color
- white
- Merck
- 14,5353
- BCS Class
- 2
- InChI
- InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
- InChIKey
- PYZRQGJRPPTADH-UHFFFAOYSA-N
- SMILES
- N1C(C2=CC=CC(Cl)=C2Cl)=C(N)N=C(N)N=1
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301
- Precautionary statements
- P264-P270-P301+P310-P405-P501
- Hazard Codes
- T,Xi,F
- Risk Statements
- 25-36/37/38-39/23/24/25-23/24/25-11
- Safety Statements
- 45-36-26-36/37-16
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- XY5850700
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29336990
- Toxicity
- LD50 in mice, rats (mg/kg): 250, >640 orally (Sawyer)
Use
With AEDs Plasma concentration of lamotrigine is increased by the glucuronidation inhibitor valproate (reduce lamotrigine dose to avoid increased risk of toxicity). Plasma concentration of lamotrigine is reduced by the glucuronidation inducers carbamazepine, phenytoin, phenobarbital and primidone. Lamotrigine can raise concentration of active metabolite of carbamazepine (conflicting evidence). With other drugs Plasma concentration of lamotrigine is reduced by the glucuronidation inducers oestrogens, rifampicin, and ritonavir (consider increasing the dose of lamotrigine). Plasma concentration of lamotrigine is possibly increased by desogestrel. With alcohol/food There are no known specific interactions between alcohol and lamotrigine, and there are no specific foods that must be excluded from diet when taking lamotrigine.
173 India supplier list of "Lamotrigine"
- Product Name:Lamotrigine API
- Products Intro:Purity: 98% | Package: 50 MG; 100 MG; 250 MG ; 20 GM
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Lamotrigine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Lamotrigine
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Uttar Pradesh,INDIA
- Product Name:Lamotrigine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Lamotrigine
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Lamotrigine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Bangalore,INDIA
- Product Name:Lamotrigine
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Lamotrigine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:Lamotrigine
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Lamotrigine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA