Lofexidine hydrochloride
Lofexidine hydrochloride
- CAS:
- 21498-08-8
- MF:
- C11H13Cl3N2O
- MW:
- 295.59
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Company Type
Properties
- Melting point:
- 230-232°C
- storage temp.
- -20°C Freezer
- solubility
- H2O: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- InChI
- InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H
- InChIKey
- DWWHMKBNNNZGHF-UHFFFAOYSA-N
- SMILES
- C1(=C(Cl)C=CC=C1Cl)OC(C)C1=NCCN1.Cl
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301
- Precautionary statements
- P301+P310
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- HazardClass
- 6.1
- Toxicity
- LD50 in mice, rats, dogs (mg/kg): between 74-147 orally (all species); between 8-18 i.v. (all species) (Tsai)
Use
Lofexidine hydrochloride is an α2-adrenergic receptor agonist (Kd = 7.6 nM for rat cerebral cortex membranes) that has transient antihypertensive effects. It is used in managing opioid withdrawal symptoms during detoxification from heroin and methadone.
2 India supplier list of "Lofexidine hydrochloride"
- Product Name:Lofexidinehydrochloride
- Products Intro:Brand:sigma aldrich | Product Number:SML1019 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Lofexidine hydrochloride 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.164009
- Company Type: Trader
- Country/Region: INDIA
- Product Name:LofexidineHydrochloride
- Products Intro:Brand:clearsynth | Product Number:CS-T-57287
- Company Type: Trader
- Country/Region: INDIA
- Product Name:LOFEXIDINE HYDROCHLORIDE
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Lofexidine hydrochloride
- Products Intro:Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
- Company Type: Trader
- Country/Region: CHINA
- Product Name:lofexidine hydrochloride
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Lofexidine hydrochloride
- Products Intro:Purity: 98% | Package: 1KG;1.8USD
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Lofexidine hydrochloride USP/EP/BP
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:LOFEXIDINE HYDROCHLORIDE
- Products Intro:Purity: 99% | Package: USP EP CP
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Lofexidine hydrochloride
- Products Intro:Purity: 98% | Package: 1g,10g,25g,100g,500g,1kg
- Company Type: Trader
- Country/Region: CHINA