METHAQUALONE

CAS:: 72-44-6

MF:: C16H14N2O

MW:: 250.3

Properties

Melting point:: 120℃

Boiling point:: 393.43°C (rough estimate)

Density: 1.16±0.1 g/cm3 (20 ºC 760 Torr)

refractive index: 1.6240 (estimate)

Flash point:: 9℃

storage temp.: −20°C

solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml

form: A neat solid

pka: pKa 2.54(H2O,t undefined,I=0.1) (Uncertain)

Water Solubility: 299.9mg/L(23 ºC)

Safety Information

Symbol(GHS): GHS02,GHS06,GHS08

Signal word: Danger

Hazard statements: H225-H301+H311+H331-H370

Precautionary statements: P210-P260-P280-P301+P310-P311

Hazard Codes: F,T

Risk Statements: 11-23/24/25-39/23/24/25

Safety Statements: 7-16-36/37-45

RIDADR: 3249

WGK Germany: 1

HazardClass: 6.1(b)

PackingGroup: III

Toxicity: LD50 orally in rats: 255 mg/kg (Goldenthal)

Use

Methaqualone, a quinazolone derivative, was introduced in 1965 for use as a sedative-hypnotic drug. It is widely abused and is associated with severe withdrawal symptoms. Methaqualone is controlled under Schedule IV of the 1971 Convention of Psychotropic Substances. (Reference: (UNCPS4) United Nations Convention on Psychotropic Substances (IV),1971)

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