Monoethyl fumarate manufacturers and suppliers in india

Monoethyl fumarate

Properties

Melting point:: 66-68 °C (lit.)

Boiling point:: 147 °C/16 mmHg (lit.)

Density: 1.1109

refractive index: 1.4500 (estimate)

storage temp.: Refrigerator

solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form: Crystalline Powder

pka: 3.45±0.10(Predicted)

color: Almost white to beige

Water Solubility: Soluble in water.

BRN: 1723588

Dielectric constant: 6.5（23.0℃）

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H317-H319-H335

Precautionary statements: P280-P302+P352-P305+P351+P338

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

WGK Germany: 1

HazardClass: IRRITANT

HS Code: 29171900

Use

Monoethyl fumarate is the Monoethyl ester form of fumarate. It is a kind of effective preservative and polymerization agent for macromolecular material. Monoethyl fumarate is capable of inhibiting the growth of bacteria, yeast and mold and prolonging the storage time of feed can. It can also be used for long-term systemic therapy in the treatment of psoriasis (a chronic hyperproliferative inflammatory skin disorder). It is the most active ingredient in the antipsoriasis drug Fumadem. The mechanism is likely to be related to its effect of improvement of keratinocyte differentiation and inhibition of keratinocyte proliferation. Monomethyl fumarate has beneficial effects on the inflamed bloodbrain barrier. It increases levels of endogenous antioxidant proteins in brain endothelial cells and reduces expression of VCAM-1 in inflamed brain endothelial cells. Transendothelial monocyte migration is limited upon MMF treatment.