Niraparib
Niraparib
- CAS:
- 1038915-60-4
- MF:
- C19H20N4O
- MW:
- 320.39
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Company Type
Properties
- Melting point:
- 187-189°C
- Boiling point:
- 463.6±45.0 °C(Predicted)
- Density
- 1.34
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 15.36±0.30(Predicted)
- form
- Solid
- color
- Pale Yellow to Light Yellow
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H332-H335
- Precautionary statements
- P261-P280-P305+P351+P338
Use
The synthesis and initial pharmacology of niraparib have been published. Niraparib has affinity for PARP 1 and 2 inhibition (IC50 = 3.8 and 2.1 nM, respectively) and inhibits the proliferation of cancer cells with mutant BRCA1 and BRCA2 with IC50 values in the 10100 nM range in vitro. Niraparib demonstrated efficacy as a single agent in a xenograft model of BRCA1-deficient cancer. Niraparib has also been reported to act as a preclinical radiosensitiser and has entered into clinical oncology trials.
4 India supplier list of "Niraparib"
- Product Name:Niraparib Base
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Niraparib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Niraparib
- Products Intro:Purity: 99% | Package: 1kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:MK-4827 98.00%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.030176
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Niraparib
- Products Intro:Brand:synzeal | Product Number:100215343
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Niraparib
- Products Intro:Brand:clearsynth | Product Number:CS-AN-00269
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Niraparib
- Products Intro:Brand:pharmaffiliates | Product Number:PA1486000
- Company Type: Trader
- Country/Region: INDIA
- Product Name:MK-4827
- Products Intro:Brand:ajchemicals | Product Number:JDH-34029 | Purity:98+%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Niraparib
- Products Intro:Purity: 99% | Package: 1kg; 25kg; 100kg or More
- Company Type: Manufacturer
- Country/Region: CHINA
- Product Name:Niraparib base
- Products Intro:Purity: 0.99 | Package: 1G；100G;1KG
- Company Type: Trader
- Country/Region: CHINA