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OXAZEPAM
OXAZEPAM
- CAS:
- 604-75-1
- MF:
- C15H11ClN2O2
- MW:
- 286.71
Properties
- Melting point:
- 205-206°
- Boiling point:
- 506.5±50.0 °C(Predicted)
- Density
- 1.3052 (rough estimate)
- refractive index
- 1.5200 (estimate)
- Flash point:
- 11 °C
- storage temp.
- −20°C
- solubility
- Practically insoluble in water, slightly soluble in ethanol (96 per cent).
- pka
- pKa 1.6/11.6(5% MeOH in H2O,t =20,I=0.15) (Uncertain)
- Water Solubility
- 20mg/L(22 ºC)
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Warning
- Hazard statements
- H336-H351
- Precautionary statements
- P202-P261-P271-P280-P304+P340+P312-P308+P313
- Hazard Codes
- Xn,T,F
- Risk Statements
- 40-39/23/24/25-23/24/25-11
- Safety Statements
- 7-16-36/37-45
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 3
- RTECS
- DF1400000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2933910000
- Toxicity
- LD50 in mice, rats (mg/kg): >5010, >5010 orally (Goldenthal)
Use
Oxazepam, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazpin-2-one (Serax), isan active metabolite of both chlordiazepoxide and diazepamand can be considered a prototype for the 3-hydroxy benzo-diazepines. It is much more polar than diazepam. Oxazepam is rapidlyinactivated to glucuronidated metabolites that are excretedin the urine. Thus, the half-life of oxazepam is about 4 to 8hours, and it is marketed as a short-acting anxiolytic. As aresult, its cumulative effects with chronic therapy are muchless than with long-acting benzodiazepine such as chlordiazepoxideand diazepam.
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