Phenformin manufacturers and suppliers in india

Phenformin

Properties

Melting point:: 176.5 °C

Boiling point:: 333.94°C (rough estimate)

Density: 1.0541 (rough estimate)

refractive index: 1.6380 (estimate)

pka: pKa 3.1/12.9±0.01(H2O,t =25,I>0.1) (Uncertain)

CAS DataBase Reference: 114-86-3(CAS DataBase Reference)

NIST Chemistry Reference: Imidodicarbonimidic diamide, n-(2-phenylethyl)-(114-86-3)

Safety Information

Hazard Codes: Xn

Risk Statements: 22

Safety Statements: 36

WGK Germany: 3

RTECS: DU2200000

HS Code: 2925290090

Hazardous Substances Data: 114-86-3(Hazardous Substances Data)

Toxicity: LD50 orl-rat: 1650 mg/kg BCFAAI 110,470,71

Use

Phenformin, a biguanide with oral hypoglycaemic activity, was introduced in 1957 for the management of diabetes mellitus. By 1970 its use had been associated with incidences of lactic acidosis and by 1976 clinical studies had conclusively demonstrated that the hazards of phenformin treatment outweighed the benefits. Preparations containing phenformin were withdrawn in several countries and their use restricted in others. Elsewhere, however, proprietary preparations containing this drug may remain available. The related biguanide, buformin, has been also associated with lactic acidosis and has been subjected to similar restrictions as phenformin, whereas there is some evidence that metformin is less liable to induce lactic acidosis. (Reference: (WHODI) WHO Drug Information, 2, 4, 1977)