Propylthiouracil manufacturers and suppliers in india

Propylthiouracil

Properties

Melting point:: 218-220 °C (lit.)

Density: 1.1880 (rough estimate)

refractive index: 1.5960 (estimate)

Flash point:: 300 °C

storage temp.: 2-8°C

solubility: 1.1g/l

form: Solid

pka: pKa 7.8; 8.3 (Uncertain)

color: White

PH: 6-7.5 (5g/l, H2O, 20℃)(slurry)

Water Solubility: 1.1 g/L

Merck: 14,7869

BRN: 130039

BCS Class: 3

Stability:: Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive.

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H302-H351

Precautionary statements: P280-P301+P312+P330

Hazard Codes: Xn,Xi

Risk Statements: 22-40

Safety Statements: 36/37-45

WGK Germany: 3

RTECS: YR1400000

Hazard Note: Harmful/Irritant

HS Code: 29335995

Toxicity: LD50 orally in Rabbit: 1250 mg/kg

Use

Propylthiouracil is useful in the treatment of hyperthyroidism.There is a delay in appearance of its effects because propylthiouracildoes not interfere with the activity of thyroid hormonesalready formed and stored in the thyroid gland. Thislag period may vary from several days to weeks, dependingon the condition of the patient. The need for three equallyspaced doses during a 24-hour period is often stressed, butevidence now indicates that a single daily dose is as effectiveas multiple daily doses in the treatment of most hyperthyroidpatients.