Pyrazinamide
Pyrazinamide
- CAS:
- 98-96-4
- MF:
- C5H5N3O
- MW:
- 123.11
Suppliers by country/region
- India(81)
- China(222)
- United States(61)
- Singapore(1)
- Germany(15)
- United Kingdom(21)
- Canada(3)
- Belgium(3)
- Japan(4)
- France(3)
- Europe(3)
- Slovakia(1)
- Ukraine(1)
- The Netherlands(2)
- Switzerland(4)
- Slovenia(1)
- Thailand(1)
- Poland(1)
- Indonesia(1)
- Brazil(1)
- Spain(2)
- Austria(1)
- South Korea(1)
- Nigeria(1)
- Nepal(1)
- Malaysia(1)
Company Type
Properties
- Melting point:
- 189-191 °C (lit.)
- Boiling point:
- 229.19°C (rough estimate)
- Density
- 1.3260 (rough estimate)
- refractive index
- 1.5900 (estimate)
- Flash point:
- >110°(230°F)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble50mg/mL
- form
- Crystalline Powder or Needles
- pka
- 0.5(at 25℃)
- color
- White
- PH
- 7 (H2O)
- Water Solubility
- 15 mg/mL
- Merck
- 14,7956
- BRN
- 112306
- BCS Class
- 1,3
- LogP
- -0.600
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P271-P280
- Hazard Codes
- F,C
- Risk Statements
- 11-34
- Safety Statements
- 22-24/25-45-36/37/39-26-16
- WGK Germany
- 3
- RTECS
- UQ2275000
- TSCA
- Yes
- HS Code
- 29339990
- Toxicity
- LD50 intraperitoneal in mouse: 1680mg/kg
Use
Pyrazinecarboxamide (PZA) occurs as a white crystalline powder that is sparingly soluble in water and slightly soluble in polar organic solvents. Its antitubercular properties were discovered as a result of an investigation of heterocyclic analogs of nicotinic acid, with which it is isosteric. Pyrazinamide has recently been elevated to first-line status in short-term tuberculosis treatment regimens because of its tuberculocidal activity and comparatively low short-term toxicity. Since pyrazinamide is not active against metabolically inactive tubercle bacilli, it is not considered suitable for long-term therapy. Potential hepatotoxicity also obviates long-term use of the drug. Pyrazinamide is maximally effective in the low pH environment that exists in macrophages (monocytes). Evidence suggests bioactivation of pyrazinamide to pyrazinoic acid by an amidase present in mycobacteria.
81 India supplier list of "Pyrazinamide"
- Product Name:Pyrazinamide
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Pyrazinamide
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Pyrazinamide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Pyrazinamide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Pyrazinamide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Pyrazinamide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Pyrazinamide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:PYRAZINAMIDE BP
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: New Delhi,INDIA
- Product Name:Pyrazinamide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Pyrazinamide
- Products Intro:Purity: 99% | Package: Kg to Mtons
- Company Type: Reagent
- Country/Region: Telangana,INDIA