Raloxifene
Raloxifene
- CAS:
- 84449-90-1
- MF:
- C28H27NO4S
- MW:
- 473.58
Suppliers by country/region
Company Type
Properties
- Melting point:
- 250-253°C
- Boiling point:
- 728.2±60.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- DMSO: 28 mg/mL, soluble
- pka
- 8.83±0.15(Predicted)
- form
- solid
- color
- light yellow
- Water Solubility
- 560μg/L at 25℃
- LogP
- 6.09
Safety Information
- Symbol(GHS)
GHS08,GHS09,GHS06
- Signal word
- Danger
- Hazard statements
- H411-H360-H311
- Precautionary statements
- P280-P302+P352-P312-P322-P361-P363-P405-P501
- WGK Germany
- 3
- HS Code
- 29349990
Use
Raloxifene, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone (Evista), is a benzothiophene derivativethat differs slightly from the triphenylethyleneSERMs. A key structural difference is the carbonyl “hinge”that connects the modified phenolic side chain to the benzothiophenering system. This hinge is the key structural elementthat leads to the differing actions at the ERs.Raloxifene, unlike tamoxifen and toremifene, has antagonistproperties on the endometrium and breast tissue and agonistproperties on bone and the cardiovascular system. The lackof agonist action on endometrial tissue has been suggestedas a reason for the lack of endometrial cancer associatedwith raloxifene use. Raloxifene is approved for the preventionand treatment of osteoporosis in postmenopausalwomen. It has also been investigated for preventing breastcancer in comparison with tamoxifen. Recent studies indicatesthat it has similar effectiveness to tamoxifen, but has apreferable side effect profile.
7 India supplier list of "Raloxifene"
- Product Name:Raloxifene
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Raloxifene
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Raloxifene
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Raloxifene
- Products Intro:Brand:pharmaffiliates | Product Number:PA1859000
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Raloxifene
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Raloxifene
- Products Intro:Purity: 99% min | Package: 1kg;1330USD
- Company Type: Trader
- Country/Region: CHINA
$1330.00/ 1kg