Retigabine
RETIGABINE
- CAS:
- 150812-12-7
- MF:
- C16H18FN3O2
- MW:
- 303.33
Suppliers by country/region
Company Type
Properties
- Boiling point:
- 430.0±45.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- Flash point:
- 2℃
- storage temp.
- 2-8°C
- solubility
- DMSO: >15mg/mL
- form
- powder
- pka
- 13.12±0.70(Predicted)
- color
- white to light brown
- BRN
- 8072099
- Stability:
- Hygroscopic
Safety Information
- Symbol(GHS)
GHS06,GHS09
- Signal word
- Danger
- Hazard statements
- H301+H331-H410
- Precautionary statements
- P261-P264-P270-P273-P301+P310-P304+P340+P311
- Hazard Codes
- T,N,Xn,F,Xi
- Risk Statements
- 23-25-50/53-36-20/21/22-11
- Safety Statements
- 45-60-61-36/37-16-26
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- DEA Controlled Substances
- CSCN: 2779
CAS SCH: V
NARC: N
Use
Retigabine was approved in March 2011 by the European Commission for the adjunctive treatment of partial-onset seizures in adults who have epilepsy; in June 2011, the U.S. FDA approved the same drug, known in the United States as ezogabine. Retigabine differs from all currently approved antiepileptic drugs in that it acts as a selective positive allosteric modulator (opener) of KCNQ2-5 potassium channels, which are key regulators of neuronal excitability. The discovery of retigabine was based on modification of an analgesic agent flupirtine that had serendipitously shown potent anticonvulsant activity in animal models of epilepsy. Changing a central 2,3,6-triaminopyridine to a 1,2,4-triaminobenzene decreased analgesic activity while enhancing antiepileptic activity. Retigabine (D-23129) was shown to be a broad spectrum anticonvulsant with oral activity in a variety of animal models. The mechanism of action of retigabine was discovered well after its in vivo activity was recognized. Retigabine can be prepared by reductive amination of 2-ethoxycarbonylamino-5-(4-fluorobenzylamino)- nitrobenzene with 4-fluorobenzaldehyde, followed by hydrogenation in the presence of Raney nickel.
5 India supplier list of "RETIGABINE"
- Product Name:Retigabine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Retigabine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Retigabine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Retigabine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Retigabinesolution
- Products Intro:Brand:sigma aldrich | Product Number:R-018 | Purity:1.0?mg/mLinacetonitrile,ampuleof1?mL,certifiedreferencematerial,Cerilliant?
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Retigabine
- Products Intro:Brand:pharmaffiliates | Product Number:PA1897000
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Retigabine Api
- Company Type: Reagent
- Country/Region: INDIA
$50.00/ 25KG
- Product Name:Retigabine
- Products Intro:Purity: 99% | Package: 25KG;50USD
- Company Type: Service provider
- Country/Region: CHINA