Thiabendazole
Thiabendazole
- CAS:
- 148-79-8
- MF:
- C10H7N3S
- MW:
- 201.25
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Properties
- Melting point:
- 298-301°C
- Boiling point:
- 446.0±37.0 °C(Predicted)
- Density
- 1.2271 (rough estimate)
- vapor pressure
- Negligible at room temperature
- refractive index
- 1.5500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in methanol and dimethyl sulfoxide.
- form
- powder
- pka
- pKa 4.7 (Uncertain)
- color
- light yellow
- Water Solubility
- 0.005 g/100 mL
- Merck
- 14,9289
- BRN
- 611403
- InChIKey
- WJCNZQLZVWNLKY-UHFFFAOYSA-N
- LogP
- 2.470
Safety Information
- Symbol(GHS)
GHS09
- Signal word
- Warning
- Hazard statements
- H410
- Precautionary statements
- P273-P501
- Hazard Codes
- N,Xi
- Risk Statements
- 50/53-36/37/38
- Safety Statements
- 60-61-36-26
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 2
- RTECS
- DE0700000
- TSCA
- Yes
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29341000
- Toxicity
- LD50 in mice, rats, rabbits (g/kg): 3.6, 3.1, >3.8 orally (Robinson)
Use
2-(4-Thiazolyl)benzimidazole (Mintezol) occurs as a whitecrystalline substance that is only slightly soluble in waterbut is soluble in strong mineral acids. Thiabendazole is abasic compound with a pKa of 4.7 that forms complexeswith metal ions.Thiabendazole inhibits the helminth-specific enzymefumarate reductase. It is not known whether metal ionsare involved or if the inhibition of the enzyme is related tothiabendazole’s anthelmintic effect. Benzimidazole anthelminticdrugs such as thiabendazole and mebendazolealso arrest nematode cell division in metaphase by interferingwith microtubule assembly. They exhibit a highaffinity for tubulin, the precursor protein for microtubulesynthesis.Thiabendazole has broad-spectrum anthelmintic activity.It is used to treat enterobiasis, strongyloidiasis (threadworminfection), ascariasis, uncinariasis (hookworm infection), andtrichuriasis (whipworm infection). It has also been used torelieve symptoms associated with cutaneous larva migrans(creeping eruption) and the invasive phase of trichinosis. Inaddition to its use in human medicine, thiabendazole iswidely used in veterinary practice to control intestinalhelminths in livestock.
10 India supplier list of "Thiabendazole"
- Product Name:Thiabendazole
- Products Intro:Brand:sigma aldrich | Product Number:45684 | Purity:PESTANAL?,analyticalstandard
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Thiabendazole
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Thiabendazole
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Thiabendazole
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Thiabendazole
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Thiabendazole
- Company Type: Reagent
- Country/Region: INDIA