Troglitazone manufacturers and suppliers in india

Troglitazone

Properties

Melting point:: 184-186°C

Boiling point:: 657.0±55.0 °C(Predicted)

Density: 1.266±0.06 g/cm3(Predicted)

storage temp.: Inert atmosphere,Store in freezer, under -20°C

solubility: DMSO: 20 mg/mL

form: solid

pka: 6.34±0.50(Predicted)

color: white to yellow

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

InChIKey: GXPHKUHSUJUWKP-UHFFFAOYSA-N

Safety Information

Safety Statements: 22-24/25

WGK Germany: 2

RTECS: XJ5813130

HS Code: 29145090

Use

Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes, under the trade name Resulin?, but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPARγ agonist. The EC50 values for transactivation of human and mouse PPARγ in a cell-based assay are 0.55 and 0.78 μM, respectively. In the same assay system, no activation of PPARα and PPARδ was observed at concentrations up to 10 μM. Troglitazone binds to the PPARγ ligand-binding domain (LBD) but fails to induce interaction of the PPARγ LBD with the transcriptional coactivators SRC-1, TIF2, AIB1, p300, or TRAP220. Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 μM.