WYE-354
WYE-354
- CAS:
- 1062169-56-5
- MF:
- C24H29N7O5
- MW:
- 495.53
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Company Type
Properties
- Density
- 1.46
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- ≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 13.42±0.70(Predicted)
- color
- White to off-white
Safety Information
Use
A pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.
0 India supplier list of "WYE-354"
- Product Name:mTORKinaseInhibitorII,WYE-354-CAS1062169-56-5-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:475986 | Purity:ThemTORKinaseInhibitorII,WYE-354,alsoreferencedunderCAS1062169-56-5,controlstheb
- Company Type: Trader
- Country/Region: INDIA
- Product Name:WYE354
- Products Intro:Brand:clearsynth | Product Number:CS-T-46599
- Company Type: Trader
- Country/Region: INDIA
- Product Name:WYE-354
- Products Intro:Purity: 0.99 | Package: 5MG;10MG;50MG;100MG,1G,5G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:WYE-354
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:wye 354
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:WYE-354
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:mTOR Kinase Inhibitor II WYE-354 WYE354
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: Wye354 Wye-354
- Company Type: Trader
- Country/Region: CHINA
- Product Name:WYE-354；WYE 354;WYE354
- Products Intro:Package: 1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Reagent
- Country/Region: UNITED STATES
- Product Name:WYE-354
- Products Intro:Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
- Company Type: Trader
- Country/Region: CHINA