Halofuginone Hydrochloride
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- Product name: Halofuginone Hydrochloride
- CAS: 1217623-74-9
- MF: C16H18BrCl2N3O3
- MW: 451.14242
- EINECS:
- MDL Number:MFCD09839202
- Synonyms:Halofuginone HCl;4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, hydrochloride (1:1), rel-;CID 46781676
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Properties
Melting point :247-249°C (dec.)
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :DMSO: soluble; Water: soluble
form :A crystalline solid
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :DMSO: soluble; Water: soluble
form :A crystalline solid
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga. It has antimalarial and anticoccidial actions. In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells. Through this action, halofuginone blocks fibrosis and tumor progression in a variety of different models. This compound also competitively inhibits prolyl-tRNA synthetase (Ki = 18.3 nM), activating the amino acid starvation response. This prevents the differentiation of TH17 cells, blunting an autoimmune response.More related product prices
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Suppliers and manufacturers
CLEARSYNTH LABS LTD.
Pharmaffiliates Analytics and Synthetics P. Ltd
Pharma Affiliates
Zibo Hangyu Biotechnology Development Co., Ltd
Guangzhou CATO Research Chemicals Inc.
TCI (Shanghai) Chemical Trading Co., Ltd.
Cayman Chemical Company
Shandong Mopai Biotechnology Co., Ltd
LGC Science (Shanghai) Ltd.
BOC Sciences