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ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Pyridine derivatives >4-(Trifluoromethyl)nicotinic acid

4-(Trifluoromethyl)nicotinic acid

4-(Trifluoromethyl)nicotinic acid Structure
  • ₹4300 - ₹15966.88
  • Product name: 4-(Trifluoromethyl)nicotinic acid
  • CAS: 158063-66-2
  • MF: C7H4F3NO2
  • MW: 191.11
  • EINECS:623-902-1
  • MDL Number:MFCD00082626
  • Synonyms:4-(Trifluoromethyl)pyridine-3-carboxylic acid, 3-Carboxy-4-(trifluoromethyl)pyridine;FlonicaMide Metabolite (TFNA type, 4-TriuoroMethyl nicotinic acid);4-(TrifluoroMethyl)-3-Pyridinecarboxylic Acid;3-Pyridinecarboxylic acid, 4-(trifluoromethyl)-;4-(Trifluoromethyl)pyridine-3-carboxylic acid 98%;4-(Trifluoromethyl)pyridine-3-carboxylic acid, >=98%;4-(TRIFLUOROMETHYL)NICOTINIC ACID;BUTTPARK 43\57-42
3 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1G
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberT2742
  • Product description4-(Trifluoromethyl)nicotinic Acid min. 98.0 %
  • Packaging1G
  • Price₹4300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2742
  • Product description4-(Trifluoromethyl)nicotinic Acid min. 98.0 %
  • Packaging5G
  • Price₹14300
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number518697
  • Product description4-(Trifluoromethyl)pyridine-3-carboxylic acid 98%
  • Packaging1G
  • Price₹15966.88
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) T2742 4-(Trifluoromethyl)nicotinic Acid min. 98.0 % 1G ₹4300 2022-05-26 Buy
TCI Chemicals (India) T2742 4-(Trifluoromethyl)nicotinic Acid min. 98.0 % 5G ₹14300 2022-05-26 Buy
Sigma-Aldrich(India) 518697 4-(Trifluoromethyl)pyridine-3-carboxylic acid 98% 1G ₹15966.88 2022-06-14 Buy

Properties

Melting point :146-148 °C(lit.)
Boiling point :290.4±40.0 °C(Predicted)
Density :1.484±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
pka :2.50±0.36(Predicted)
form :Solid
color :Pale Yellow to Dark Yellow
InChIKey :LMRJHNFECNKDKH-UHFFFAOYSA-N
CAS DataBase Reference :158063-66-2(CAS DataBase Reference)
EPA Substance Registry System :3-Pyridinecarboxylic acid, 4-(trifluoromethyl)- (158063-66-2)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

4-(Trifluoromethyl)-3-Pyridinecarboxylic Acid is a useful synthetic intermediate. It can be used to prepare pyridine carboxamides as palm site inhibitors of HCV NS5B polymerase. It can also be used to synthesize pyrazolylcarboxanilides as Ca2+ release-activated Ca2+ (CRAC) channel inhibitors.

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