15(S)-FLUPROSTENOL
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- Product name: 15(S)-FLUPROSTENOL
- CAS: 54276-24-3
- MF: C23H29F3O6
- MW: 458.47
- EINECS:
- MDL Number:MFCD08062232
- Synonyms:9ALPHA,11ALPHA,15S-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;Travoprost Impurity 19（15(S)-Fluprostenol）;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, (5Z)-;TravoprostImpurity19-Fluprostenol);15(S)-FLUPROSTENOL
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Properties
Boiling point :608.0±55.0 °C(Predicted)
Density :1.335±0.06 g/cm3(Predicted)
solubility :DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 5 mg/ml
pka :4.76±0.10(Predicted)
Density :1.335±0.06 g/cm3(Predicted)
solubility :DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 5 mg/ml
pka :4.76±0.10(Predicted)
Safety Information
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Description
(+)-15(R)-Fluprostenol isopropyl ester is a prodrug (Travoprost) which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, (+)-15(R)-fluprostenol, is a potent FP receptor agonist. The 15(R)-epimers of most prostaglandins are about 100 times less potent than the natural, 15(S)-isomers. However, the neighboring phenoxy group at C-16 reverses the absolute configuration at C-15 in the fluprostenol series; hence, 15(S)-fluprostenol is less active as an FP agonist than 15(R)-fluprostenol. The biology of 15(S)-fluprostenol has not been widely studied.Related product price
- Fluprostenol
₹16259.15
Suppliers and manufacturers
China National Standard Pharmaceutical Corporation Limited
Cayman Chemical Company
Shanghai Kewel Chemical Co., Ltd.
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd
Hubei Yangxin Medical Technology Co., Ltd.
Nantong Hanfang Biotechnology Co. , Ltd.
Shanghai EFE Biological Technology Co., Ltd.
TargetMol Chemicals Inc.
AXXORA, LLC
Shenzhen Xinbosheng Biological Technology Co., Ltd.