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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Structure
  • ₹14590
  • Product name: Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
  • CAS: 176199-48-7
  • MF: C8H11NO4
  • MW: 185.18
  • EINECS:
  • MDL Number:
  • Synonyms:Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI);Eglumegad;Eglumetad;LY 354740;(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid;Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-aMino-, [1S-(1a,2b,5a,6a)]-;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,2-amino-,(1S,2S,5R,6S)-;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S...
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product number5.04685
  • Product descriptionLY 354740 - CAS 176199-48-7 - Calbiochem
  • Packaging10MG
  • Price₹14590
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 5.04685 LY 354740 - CAS 176199-48-7 - Calbiochem 10MG ₹14590 2022-06-14 Buy

Properties

Melting point :270-271 °C
Boiling point :376.4±32.0 °C(Predicted)
Density :1.569
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :H2O : 6.33 mg/mL (34.18 mM; Need ultrasonic and warming)
form :Powder
pka :2.06±0.40(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

LY 354740 is a highly selective and potent mGluR-2/3 (group II mGlu receptor) agonist. LY 354740 has been shown to be a conformationally constrained analog of glutamate with the ability to decrease forskolin-stimulated cAMP formation by more than 90%. Recent studies have found that activation of presynaptic metabotropic mGluR-2/3 induces long lasting inhibition of P/Q-type Ca2+ channels and the cAMP/protein kinase A pathway.

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