2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
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- ₹20010 - ₹49059
- Product name: 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
- CAS: 18080-67-6
- MF: C10H8Br2N2O2
- MW: 347.99
- EINECS:
- MDL Number:MFCD00186742
- Synonyms:2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE;2,3-bis(broMoMethyl)-1-oxoquinoxalin-1-iuM-4(1H)-olate;Conoidin A;Quinoxaline, 2,3-bis(bromomethyl)-, 1,4-dioxide;antioxidative,antioxidant,heart disease,Parasite,Inhibitor,Peroxiredoxin II,hyperperoxidation,Conoidin A,ischaemic,inhibit,neuroprotective
4 prices
Selected condition：
Brand
- Sigma-Aldrich
- Sigma-Aldrich(India)
- ottokemi
Package
- 25MG
- 100mg
- ManufacturerSigma-Aldrich
- Product number5.30746
- Product descriptionPeroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem A cell-permeable nematicidal compound that covalently binds to the peroxidatic cysteine of peroxiredoxin II in T. gondii and irreversibly blocks its hyperperoxidation activity (IC?? = 23 μM).
- Packaging25MG
- Price₹20010
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number5.30746
- Product descriptionPeroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem A cell-permeable nematicidal compound that covalently binds to the peroxidatic cysteine of peroxiredoxin II in T. gondii and irreversibly blocks its h
- Packaging25MG
- Price₹20010
- Updated2022-06-14
- Buy
- Manufacturerottokemi
- Product number C 6669
- Product descriptionConoidin A
- Packaging25mg
- Price₹39906
- Updated2022-05-26
- Buy
- Manufacturerottokemi
- Product number C 6669
- Product descriptionConoidin A
- Packaging100mg
- Price₹49059
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.30746 | Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem A cell-permeable nematicidal compound that covalently binds to the peroxidatic cysteine of peroxiredoxin II in T. gondii and irreversibly blocks its hyperperoxidation activity (IC?? = 23 μM). | 25MG | ₹20010 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.30746 | Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem A cell-permeable nematicidal compound that covalently binds to the peroxidatic cysteine of peroxiredoxin II in T. gondii and irreversibly blocks its h | 25MG | ₹20010 | 2022-06-14 | Buy |
| ottokemi | C 6669 | Conoidin A | 25mg | ₹39906 | 2022-05-26 | Buy |
| ottokemi | C 6669 | Conoidin A | 100mg | ₹49059 | 2022-05-26 | Buy |
Properties
Melting point :180-190 °C (decomp)
Boiling point :512.3±60.0 °C(Predicted)
Density :1.95±0.1 g/cm3(Predicted)
solubility :DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml
form :A crystalline solid
pka :1.91±0.30(Predicted)
color :White to yellow
Boiling point :512.3±60.0 °C(Predicted)
Density :1.95±0.1 g/cm3(Predicted)
solubility :DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml
form :A crystalline solid
pka :1.91±0.30(Predicted)
color :White to yellow
Safety Information
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Description
Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and act in redox signaling pathways. Increased expression of human peroxiredoxin is associated with cancer, cardiovascular dysfunction, and neurodegeneration. Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine on the enzyme. It has been shown to inhibit peroxiredoxin II (IC50 = 23 μM) in the parasite T. gondii and peroxiredoxin I in the hookworm A. ceylanicum. At 5 μM, conoidin A can also inhibit the glucose oxidase-mediated hyperoxidation of mammalian peroxiredoxin I and II, but not peroxiredoxin III.Related product price
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₹12930