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(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide

(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide Structure
  • ₹0
  • Product name: (S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide
  • CAS: 214398-99-9
  • MF: C7H11ClN2O2
  • MW: 190.63
  • EINECS:1308068-626-2
  • MDL Number:MFCD11845729
  • Synonyms:vildagliptin Impurity I;-1-(2-Chloroacetyl);(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide;2-PyrrolidinecarboxaMide,1-(2-chloroacetyl)-, (2S)-;Vildagliptin Impurity 55;Vildagliptin Impurity 8/Vildagliptin Chloroacetyl Amide (S)-Isomer/(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxamide;Vildagliptin?Chloroacetyl Amide (S)-Isomer;1-(Chloroacetyl)-L-prolinamide
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :133-137℃ (isopropyl ether )
Boiling point :442.5±45.0 °C(Predicted)
Density :1.353±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Very Slightly)
form :Solid
pka :15.56±0.20(Predicted)
color :White to Pale Beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamide is used in the synthesis of Vildagliptin (V305000), an oral anti-diabetic drug, and its impurities (H971380) (Impurity A).

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(S)-Pyrrolidine-2-carbonitrile hydrochloride (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile CHLOROAC-PRO-OH N-acetic acid-1-aMino-3-adaMantanol 5-Vinylpyrrolidone Dichloroacetyl chloride CYCLO(-GLY-PRO) VIGABATRIN 4-Aminobutyric acid 1378466-25-1 Vildagliptin iMpurity K D-Prolinamide 2133-40-6 Amantadine 3-Amino-1-hydroxyadamantane Cyanuric acid Vildagliptin Carboxy Acid Metabolite Trifluoroacetate 1,3-Dihydroxyadamantane Vildagliptin

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Suppliers and manufacturers

TAGOOR LABORATORIES PVT LTD SRINIVASA LABS SynThink RESEARCH CHEMICALS SRIGEN LIFE SCIENCES PVT LTD Bajaj Healthcare Ltd Arnavi Laboratory KARPSCHEM LABORATORIES CLEARSYNTH LABS LTD. SynZeal Research Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd