5,15-DIPHENYL-21H,23H-PORPHINE
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- ₹7900 - ₹34943.1
- Product name: 5,15-DIPHENYL-21H,23H-PORPHINE
- CAS: 22112-89-6
- MF: C32H22N4
- MW: 462.54
- EINECS:
- MDL Number:MFCD08276335
- Synonyms:5,15-DIPHENYL-21H,23H-PORPHINE;5,15-DIPHENYLPORPHINE;5, 15-BIS-(PHENYL)PORPHYRINS;5,15-Diphenylporphyrin;5,15-Bis-(phenyl)-21H,23H-porphyrins;5,15-DPP;Stat3 Inhibitor VIII, 5,15-DPP;STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 10MG
- 25MG
- 50MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberD2860
- Product description5,15-Diphenylporphyrin
- Packaging100MG
- Price₹7900
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberD4071
- Product description5, 15-DPP
- Packaging10MG
- Price₹8822.38
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number573109
- Product descriptionSTAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem The STAT3 Inhibitor VIII, 5,15-DPP, also referenced under CAS 22112-89-6, controls the biological activity of STAT3.
- Packaging25MG
- Price₹9490
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberD4071
- Product description5, 15-DPP
- Packaging50MG
- Price₹34943.1
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | D2860 | 5,15-Diphenylporphyrin | 100MG | ₹7900 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | D4071 | 5, 15-DPP | 10MG | ₹8822.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 573109 | STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem The STAT3 Inhibitor VIII, 5,15-DPP, also referenced under CAS 22112-89-6, controls the biological activity of STAT3. | 25MG | ₹9490 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D4071 | 5, 15-DPP | 50MG | ₹34943.1 | 2022-06-14 | Buy |
Properties
Melting point :>200℃
Boiling point :912.3±65.0 °C(Predicted)
Density :1.285±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :≤2mg/ml in dimethyl formamide
form :Deep blue to deep purple solid
color :Red to Dark blue to Black
Boiling point :912.3±65.0 °C(Predicted)
Density :1.285±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :≤2mg/ml in dimethyl formamide
form :Deep blue to deep purple solid
color :Red to Dark blue to Black
Safety Information
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Description
Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. 5,15-DPP is a cell-permeable porphyrin derivative that selectively binds STAT3 (Kd = 880 nM). This inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC50 = 280 nM), preventing nuclear translocation and DNA binding. 5,15-DPP poorly inhibits STAT1 (IC50 = 10 μM) and does not affect Grb2. It reduces IL-6-dependent STAT3 activation and consequent c-myc expression in MDA-MB-468 cells and blocks TRAIL-induced migration and invasion in A549 cells. Furthermore, inhibition of JAK/STAT signaling in satellite cells via 5,15-DPP and the JAK2 inhibitor AG-490 has been used to stimulate muscle regeneration in a model of aging skeletal muscle deterioration.More related product prices
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