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7-CHLORO-1-HYDROXYISOQUINOLINE

7-CHLORO-1-HYDROXYISOQUINOLINE Structure
  • ₹0
  • Product name: 7-CHLORO-1-HYDROXYISOQUINOLINE
  • CAS: 24188-74-7
  • MF: C9H6ClNO
  • MW: 179.6
  • EINECS:
  • MDL Number:MFCD08436984
  • Synonyms:7-Chloro-1(2H)-isoquinolinone;7-CHLORO-1-HYDROXYISOQUINOLINE;7-CHLORO-1(2H)-ISOQUINOLONE;7-Chloroisoquinolin-1-ol;7-chloro-2H-isoquinolin-1-one;1(2H)-Isoquinolinone, 7-chloro-
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :245-247 °C(Solv: methanol (67-56-1))
Boiling point :414.9±45.0 °C(Predicted)
Density :1.339±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
pka :11.99±0.20(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.

Description

7-Chloroisoquinolin-1(2H)-one acts as a reagent for the preparation, SAR of methoxyisoquinoline derivative and discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection. Synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5-methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-HT3 antagonists.

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