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N-(3-PYRIDYL)-INDOMETHACIN AMIDE

N-(3-PYRIDYL)-INDOMETHACIN AMIDE Structure
  • ₹26802.7
  • Product name: N-(3-PYRIDYL)-INDOMETHACIN AMIDE
  • CAS: 261766-29-4
  • MF: C24H20ClN3O3
  • MW: 433.89
  • EINECS:
  • MDL Number:MFCD02683393
  • Synonyms:N-(3-PYRIDYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;N-(3-PYRIDYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(3-PYRIDYL)-INDOMETHACIN AMIDE;N-3PYIA;N-3PyIA, N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide;1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-3-pyridinyl-1H-indole-3-acetaMide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-3-pyridinyl-;Indomethacin N-Pyridyl Impurity
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0865
  • Product descriptionN-(3-Pyridyl)indomethacinamide ≥98%
  • Packaging5MG
  • Price₹26802.7
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P0865 N-(3-Pyridyl)indomethacinamide ≥98% 5MG ₹26802.7 2022-06-14 Buy

Properties

storage temp. :−20°C
solubility :≤3mg/ml in ethanol;3mg/ml in DMSO;3mg/ml in dimethyl formamide
form :crystalline solid

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

N-(3-pyridyl)-indomethacin amide (N-3PyIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 0.052 μM. It is about 1,300 times less potent as an inhibitor of ovine recombinant COX-1. However, N-3PyIA is not selective as an inhibitor of ovine seminal vesicular COX-1 and ovine placental COX-2. The IC50 values for ovine COX-1 and -2 are 75 and 50 μM, respectively.

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5-METHOXY-2-METHYLINDOLE

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Suppliers and manufacturers

CLEARSYNTH LABS LTD. MedBioPharmaceutical Technology Inc Cayman Chemical Company Shanghai Yifei Biotechnology Co. , Ltd. Guangzhou Isun Pharmaceutical Co., Ltd Nanjing Tengyi Biotechnology Co., Ltd SIGMA-RBI 3B Pharmachem (Wuhan) International Co.,Ltd. Toronto Research Chemicals J & K SCIENTIFIC LTD.