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ChemicalBook > Product Catalogue >Chemical Reagents >Organic reagents >fatty acid >3-Guanidinopropionic acid

3-Guanidinopropionic acid

3-Guanidinopropionic acid Structure
  • ₹5011.98 - ₹20480.9
  • Product name: 3-Guanidinopropionic acid
  • CAS: 353-09-3
  • MF: C4H9N3O2
  • MW: 131.13
  • EINECS:206-530-0
  • MDL Number:MFCD00045939
  • Synonyms:b-Alanine, N-(aMinoiMinoMethyl)-;guanidinepropanoicacid ;guanidinopropionicacid ;n-(aminoiminomethyl)-beta-alanin ;n-(aminoiminomethyl)beta-alanine ;3-(diaminomethylideneamino)propanoic acid;3-[bis(azanyl)methylideneamino]propanoic acid;GUANIDINOPROPIONIC ACID(P)
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 1G
  • 5G
  • ManufacturerSigma-Aldrich(India)
  • Product numberG6878
  • Product description3-Guanidinopropionic acid
  • Packaging1G
  • Price₹5011.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG6878
  • Product description3-Guanidinopropionic acid
  • Packaging5G
  • Price₹20480.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) G6878 3-Guanidinopropionic acid 1G ₹5011.98 2022-06-14 Buy
Sigma-Aldrich(India) G6878 3-Guanidinopropionic acid 5G ₹20480.9 2022-06-14 Buy

Properties

Melting point :222 °C (dec.)(lit.)
Boiling point :299.1±42.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :Aqueous Acid (Slightly), Water (Slightly, Heated)
form :Solid
pka :4.22±0.10(Predicted)
color :White to Off-White
BRN :1705262
LogP :-1.680 (est)
CAS DataBase Reference :353-09-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α). PGC-1α activation results in enhanced expression of AMPK, as well as genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis, increasing oxidative muscle fibers, numbers of mitochondria, and motor performance. 3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance. In aged rats, reduced mitochondrial biogenesis in response to chronic activation of AMPK with 3-guanidinopropionic acid leads to metabolic insufficiency that can contribute to muscle loss.

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