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ChemicalBook > Product Catalogue >Organic Chemistry >Carboxylic acids and derivatives >2,4-Pyridinedicarboxylic acid

2,4-Pyridinedicarboxylic acid

2,4-Pyridinedicarboxylic acid Structure
  • ₹2600 - ₹12318.85
  • Product name: 2,4-Pyridinedicarboxylic acid
  • CAS: 499-80-9
  • MF: C7H5NO4
  • MW: 167.12
  • EINECS:207-892-2
  • MDL Number:MFCD00006296
  • Synonyms:RARECHEM AL BO 0286;PYRIDINE-2,4-DICARBOXYLIC ACID;LUTIDINIC ACID;2,4-LUTIDINIC ACID;2,4-PYRIDINEDICARBOXYLIC ACID;2,4-Pyridinedicarboxylic acid hydrate;2,4-PyridinecarboxylicAcid;2,4-Pyridinedicarboxylic acid hydrate, 99+%
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5G
  • 10G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberP2416
  • Product description2,4-Pyridinedicarboxylic Acid min. 98.0 %
  • Packaging5G
  • Price₹2600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberP2416
  • Product description2,4-Pyridinedicarboxylic Acid min. 98.0 %
  • Packaging25G
  • Price₹8800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number8.21052
  • Product description2,4-Pyridinedicarboxylic acid for synthesis
  • Packaging10G
  • Price₹9600
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number04473
  • Product description2,4-Pyridinedicarboxylic acid ≥98.0%
  • Packaging5G
  • Price₹12318.85
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) P2416 2,4-Pyridinedicarboxylic Acid min. 98.0 % 5G ₹2600 2022-05-26 Buy
TCI Chemicals (India) P2416 2,4-Pyridinedicarboxylic Acid min. 98.0 % 25G ₹8800 2022-05-26 Buy
Sigma-Aldrich(India) 8.21052 2,4-Pyridinedicarboxylic acid for synthesis 10G ₹9600 2022-06-14 Buy
Sigma-Aldrich(India) 04473 2,4-Pyridinedicarboxylic acid ≥98.0% 5G ₹12318.85 2022-06-14 Buy

Properties

Melting point :243-246 °C
Boiling point :295.67°C (rough estimate)
Density :1.5216 (rough estimate)
vapor pressure :0.001Pa at 25℃
refractive index :1.6280 (estimate)
storage temp. :Store below +30°C.
solubility :2.49g/l
form :Crystalline Powder
pka :2.15(at 25℃)
color :White to almost white
Water Solubility :Soluble in water at 20°C 4.5 g/L.
λmax :258nm(MeOH aq.)(lit.)
BRN :131631
LogP :0.57
CAS DataBase Reference :499-80-9(CAS DataBase Reference)
EPA Substance Registry System :2,4-Pyridinedicarboxylic acid (499-80-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 μM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.

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