2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
![2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Structure](/CAS/GIF/500579-04-4.gif)
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- ₹9459.99 - ₹74291.98
- Product name: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
- CAS: 500579-04-4
- MF: C27H35N5
- MW: 429.6
- EINECS:
- MDL Number:MFCD14635408
- Synonyms:2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine;GANT 61;Benzenamine, 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-;2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine] GANT61;GNT61;NSC 136476;GANT61, >=98%;GANT-61,NSC 136476
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 2MG
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberG9048
- Product descriptionGANT61 ≥98% (HPLC)
- Packaging25MG
- Price₹74291.98
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberG9048
- Product descriptionGANT61 ≥98% (HPLC)
- Packaging5MG
- Price₹19452.53
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number373403
- Product descriptionInSolution Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem The InSolution Hh/Gli Antagonist, GANT61, also referenced under CAS 500579-04-4, controls the biological activity of Hh/Gli. This small molecule/inhib
- Packaging2MG
- Price₹9459.99
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G9048 | GANT61 ≥98% (HPLC) | 25MG | ₹74291.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G9048 | GANT61 ≥98% (HPLC) | 5MG | ₹19452.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 373403 | InSolution Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem The InSolution Hh/Gli Antagonist, GANT61, also referenced under CAS 500579-04-4, controls the biological activity of Hh/Gli. This small molecule/inhib | 2MG | ₹9459.99 | 2022-06-14 | Buy |
Properties
Melting point :110 - 113°C
Boiling point :549.0±50.0 °C(Predicted)
Density :1.134±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >2mg/mL
pka :5.97±0.10(Predicted)
form :powder
color :white to off-white
Boiling point :549.0±50.0 °C(Predicted)
Density :1.134±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >2mg/mL
pka :5.97±0.10(Predicted)
form :powder
color :white to off-white
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Hedgehog proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 61 is a GLI antagonist, inhibiting GLI1 activation of gene expression with an IC50 value of 5 μM. It does not affect signaling through NF-κB, glucocorticoid receptor, MAPK, HGF, C/EBPα, or HIF-1, supporting specificity for the Hedgehog pathway. GANT 61 has been shown to inhibit the in vitro proliferation of PANC-1 and 22Rv1 cancer cells, which have elevated GLI1 levels, and prevent the development of 22Rv1 tumors in mice.More related product prices
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Suppliers and manufacturers
career henan chemical co
![2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine](https://img.chemicalbook.com/ProductImageEN/2019-12/small/10552f29-11d0-4cba-bcfe-100e1b47e480.jpg)
A.J Chemicals
CLEARSYNTH LABS LTD.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
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ShenZhen Trendseen Biological Technology Co.,Ltd.
₹1.00 /100ASSAYS
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine CAS:500579-04-4
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine CAS:500579-04-4