storage temp. :Store at +4°C solubility :≥45.9 mg/mL in DMSO; insoluble in EtOH; ≥16.6 mg/mL in H2O with ultrasonic form :Powder color :Light brown to black
Safety Information
Symbol(GHS):
Signal word:
Warning
Hazard statements:
Code
Hazard statements
Hazard class
Category
Signal word
Pictogram
P-Codes
H302
Harmful if swallowed
Acute toxicity,oral
Category 4
Warning
P264, P270, P301+P312, P330, P501
H315
Causes skin irritation
Skin corrosion/irritation
Category 2
Warning
P264, P280, P302+P352, P321,P332+P313, P362
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Category 2A
Warning
P264, P280, P305+P351+P338,P337+P313P
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure;Respiratory tract irritation
Category 3
Warning
Precautionary statements:
P264
Wash hands thoroughly after handling.
P264
Wash skin thouroughly after handling.
P270
Do not eat, drink or smoke when using this product.
IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352
IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321
Specific treatment (see … on this label).
P330
Rinse mouth.
P332+P313
IF SKIN irritation occurs: Get medical advice/attention.
P362
Take off contaminated clothing and wash before reuse.
P501
Dispose of contents/container to..…
Description
The Src homology region 2 domain-containing phosphatases (SHP) known as SHP-1 and SHP-2 act downstream of receptor and non-receptor tyrosine kinase to modulate signal transduction. NSC 87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2 (IC50 = 355 and 318 nM, respectively). It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26. Through its effects on SHP-1 or SHP-2, NSC 87877 blocks epidermal growth factor receptor-induced activation of Ras and ERK1/2 in HEK293 cells, stimulates store-operated calcium entry in response to thrombin in platelets, and increased acetylcholine receptor clustering in myotubes.
