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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Antimetabolites, Antineoplastic >6-Thioguanine

6-Thioguanine

6-Thioguanine Structure
  • ₹2370.68 - ₹32442.53
  • Product name: 6-Thioguanine
  • CAS: 154-42-7
  • MF: C5H5N5S
  • MW: 167.19
  • EINECS:205-827-2
  • MDL Number:MFCD00233553
  • Synonyms:2-Amino-1,7(9)-dihydro-purine-6-thione;2-amino-6-mercaptopurine (50X)*gamma-irradiated C;2-amino-6-mercaptopurine crystalline;2-Amino-6-purinethiol (6-Thioguanine);2-AMINO-6-MERCAPTOPURINE (50X)GAMMA-IRRA DIATED CEL;Tioguanine(Thioguanine);6-Thioguanine,~97%;6-THIOGUANIDE
13 prices
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Brand

  • ALFA India
  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 2.5MG
  • 100MG
  • 250MG
  • 500MG
  • 1gm
  • 1g
  • 5g
  • ManufacturerALFA India
  • Product numberALF-B21280-03
  • Product description6-Thioguanine, 98%
  • Packaging1g
  • Price₹4173
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-B21280-06
  • Product description6-Thioguanine, 98%
  • Packaging5g
  • Price₹17493
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT0212
  • Product description6-Thioguanine
  • Packaging1G
  • Price₹4500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT0212
  • Product description6-Thioguanine
  • Packaging5G
  • Price₹13700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4882
  • Product description6-Thioguanine ≥98%
  • Packaging5G
  • Price₹32442.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4882
  • Product description6-Thioguanine ≥98%
  • Packaging1G
  • Price₹7772.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4882
  • Product description6-Thioguanine ≥98%
  • Packaging500MG
  • Price₹6516.65
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4882
  • Product description6-Thioguanine ≥98%
  • Packaging250MG
  • Price₹5412.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4882
  • Product description6-Thioguanine ≥98%
  • Packaging100MG
  • Price₹3020.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4660
  • Product description6-Thioguanine Hybri-Max?, 50?×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
  • Packaging2.5MG
  • Price₹2370.68
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number T 0184
  • Product description6-Thioguanine, ≥98%
  • Packaging100mg
  • Price₹6903
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number T 0184
  • Product description6-Thioguanine, ≥98%
  • Packaging250mg
  • Price₹9603
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number T 0184
  • Product description6-Thioguanine, ≥98%
  • Packaging1gm
  • Price₹17109
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ALFA India ALF-B21280-03 6-Thioguanine, 98% 1g ₹4173 2022-05-26 Buy
ALFA India ALF-B21280-06 6-Thioguanine, 98% 5g ₹17493 2022-05-26 Buy
TCI Chemicals (India) T0212 6-Thioguanine 1G ₹4500 2022-05-26 Buy
TCI Chemicals (India) T0212 6-Thioguanine 5G ₹13700 2022-05-26 Buy
Sigma-Aldrich(India) A4882 6-Thioguanine ≥98% 5G ₹32442.53 2022-06-14 Buy
Sigma-Aldrich(India) A4882 6-Thioguanine ≥98% 1G ₹7772.35 2022-06-14 Buy
Sigma-Aldrich(India) A4882 6-Thioguanine ≥98% 500MG ₹6516.65 2022-06-14 Buy
Sigma-Aldrich(India) A4882 6-Thioguanine ≥98% 250MG ₹5412.5 2022-06-14 Buy
Sigma-Aldrich(India) A4882 6-Thioguanine ≥98% 100MG ₹3020.18 2022-06-14 Buy
Sigma-Aldrich(India) A4660 6-Thioguanine Hybri-Max?, 50?×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma 2.5MG ₹2370.68 2022-06-14 Buy
ottokemi T 0184 6-Thioguanine, ≥98% 100mg ₹6903 2022-05-26 Buy
ottokemi T 0184 6-Thioguanine, ≥98% 250mg ₹9603 2022-05-26 Buy
ottokemi T 0184 6-Thioguanine, ≥98% 1gm ₹17109 2022-05-26 Buy

Properties

Melting point :≥300 °C(lit.)
Density :1.483 (estimate)
refractive index :1.5605 (estimate)
storage temp. :2-8°C
solubility :Practically insoluble in water and in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides.
form :lyophilized powder
pka :pKa 8.22 (Uncertain)
Boiling point :555.4±42.0 °C(Predicted)
color :Yellow to green
Water Solubility :soluble
Merck :14,9337
BRN :157765
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMF may be stored at -20°C for up to 1 month.
CAS DataBase Reference :154-42-7(CAS DataBase Reference)
EPA Substance Registry System :Thioguanine (154-42-7)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity. Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation. This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.

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