8-CHLORO-CAMP
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- ₹22992.3 - ₹38320.5
- Product name: 8-CHLORO-CAMP
- CAS: 41941-56-4
- MF: C10H11ClN5O6P
- MW: 363.65
- EINECS:
- MDL Number:MFCD00153938
- Synonyms:8-CHLOROADENOSINE-CYCLIC-3',5'-MONOPHOSPHATE;8-CHLORO-CAMP;8-CL-CAMP;8-CHLOROADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE;8-Chloro-cAMP, 8-Chloroadenosine 3μ,5μ-monophosphate, 8-Cl-cAMP;8-Chloro cyclic adenosine 3',5'-phosphate;8-Chloroadenosine 3',5'-phosphoric acid;8-Chloroadenosine 3',5'-Cyclicmonophate Sodium Salt
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product numberC1081
- Product description8-Chloroadenosine 3′,5′-cyclic-monophosphate ≥85%
- Packaging5MG
- Price₹22992.3
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberC1081
- Product description8-Chloroadenosine 3′,5′-cyclic-monophosphate ≥85%
- Packaging10MG
- Price₹38320.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C1081 | 8-Chloroadenosine 3′,5′-cyclic-monophosphate ≥85% | 5MG | ₹22992.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C1081 | 8-Chloroadenosine 3′,5′-cyclic-monophosphate ≥85% | 10MG | ₹38320.5 | 2022-06-14 | Buy |
Properties
Boiling point :731.7±70.0 °C(Predicted)
Density :2.55±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :aqueous base: soluble
form :White to off-white powder.
pka :0.95±0.60(Predicted)
color :White to light yellow
Density :2.55±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :aqueous base: soluble
form :White to off-white powder.
pka :0.95±0.60(Predicted)
color :White to light yellow
Safety Information
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Description
8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt is a site-selective cAMP analog that inhibits various cancer cell lines such as HT29 colorectal cells and ZR-75-1 breast carcinoma, which is due to selective activation of PKA (protein kinase A) isoenzymes. Studies show that 8-Chloroadenosine 3',5'-Cyclic Monophosphate down-regulates the RI α subunit and up-regulates the RII β subunit of cAMP-dependent protein kinases leading to type II holoenzyme-dependent growth inhibition of caner cells such as HL-60. In addition, it is suggested that 8-Chloroadenosine 3',5'-Cyclic Monophosphate can possibly stimulate the antitumor effect of taxanes at micromolar concentrations. Further studies show that mdr-1 mRNA expression is reduced greatly in the presence of 8-Chloroadenosine 3',5'-Cyclic Monophosphate.Related product price
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