3,3',4',5,6,7-HEXAHYDROXYFLAVONE
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- ₹32230
- Product name: 3,3',4',5,6,7-HEXAHYDROXYFLAVONE
- CAS: 90-18-6
- MF: C15H10O8
- MW: 318.24
- EINECS:201-973-6
- MDL Number:MFCD00017428
- Synonyms:QUERCETAGIN;QUERCETAGENIN;QUERCETAGETIN;3,3',4',5,6,7-HEXAHYDROXYFLAVONE;3,5,6,7,3',4'-HEXAHYDROXYFLAVONE;2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4-benzopyrone ;2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-1-benzopyran-4-one;3,5,6,7-Tetrahydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product number551590
- Product descriptionQuercetagetin - CAS 90-18-6 - Calbiochem A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC?? = 340 nM).
- Packaging5MG
- Price₹32230
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 551590 | Quercetagetin - CAS 90-18-6 - Calbiochem A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC?? = 340 nM). | 5MG | ₹32230 | 2022-06-14 | Buy |
Properties
Melting point :>300°C
Boiling point :732.4±60.0 °C(Predicted)
Density :1.912±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 125 mg/mL (392.79 mM; Need ultrasonic)
form :A crystalline solid
pka :6.12±0.40(Predicted)
color :Light yellow to yellow
LogP :2.230 (est)
Boiling point :732.4±60.0 °C(Predicted)
Density :1.912±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 125 mg/mL (392.79 mM; Need ultrasonic)
form :A crystalline solid
pka :6.12±0.40(Predicted)
color :Light yellow to yellow
LogP :2.230 (est)
Safety Information
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Description
The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. Quercetagetin is a flavonol that inhibits Pim-1 with an IC50 value of 0.34 μM. It is selective for Pim-1, inhibiting Pim-2, PKA, RSK2, and JNK with IC50 values of 3.45, 21.2, 2.82, and 4.6 μM, respectively. Quercetagetin has been shown to inhibit Pim-1 activity in intact RWPE2 prostate cancer cells with an ED50 value of 5.5 μM, which led to significant growth inhibition. It can also inhibit the growth of additional prostate epithelial cell lines at a potency proportionate to their respective level of Pim-1 protein.Related product price
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