ALPHA-APO-OXYTETRACYCLINE
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- ₹0
- Product name: ALPHA-APO-OXYTETRACYCLINE
- CAS: 18751-99-0
- MF: C22H22N2O8
- MW: 442.42
- EINECS:
- MDL Number:MFCD00062827
- Synonyms:BETA-APO-OXYTETRACYCLINE;ALPHA-APO-OXYTETRACYCLINE;β-Apo-oxytetracycline;b-Apo-oxytetracycline;Apooxytetracycline, beta-;beta-Apo-oxytetracycline, 'can be used as secondary standard';Oxytetracycline EP Impurity E;Oxytetracycline EP Impurity E/β-Apo-Oxytetracycline
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Properties
Melting point :200-204 °C
Boiling point :742.4±60.0 °C(Predicted)
Density :1.62±0.1 g/cm3(Predicted)
storage temp. :Refrigerator, Under Inert Atmosphere
solubility :Aqueous Base (Slightly), Methanol (Slightly, Heated, Sonicated)
form :Powder
pka :1.62±0.58(Predicted)
color :Yellow-brown to brown
Stability :Unstable in basic solution
EPA Substance Registry System :1-Cyclohexene-1-carboxamide, 4-(1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(dimethylamino)-2,5-dihydroxy-6-oxo- (18751-99-0)
Boiling point :742.4±60.0 °C(Predicted)
Density :1.62±0.1 g/cm3(Predicted)
storage temp. :Refrigerator, Under Inert Atmosphere
solubility :Aqueous Base (Slightly), Methanol (Slightly, Heated, Sonicated)
form :Powder
pka :1.62±0.58(Predicted)
color :Yellow-brown to brown
Stability :Unstable in basic solution
EPA Substance Registry System :1-Cyclohexene-1-carboxamide, 4-(1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(dimethylamino)-2,5-dihydroxy-6-oxo- (18751-99-0)
Safety Information
Symbol(GHS): |
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Signal word: | Warning | |||||||||||||||||||||
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Description
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.More related product prices
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